Block 1 Lecture 10 -- Inflammation Flashcards
1
Q
What are the components of inflammation?
A
1) vasodilation
2) immune mediators
3) cellular migration
2
Q
What is the initial allergic response to a protein?
A
1) DCs and T cells release IL-8 and recruit mast cells
2) DCs release TNF for vasodilation
3
Q
How do WBCs do diapedesis?
A
selectin (vessel) - integrin (cell)
4
Q
How is IgE produced in an allergic response?
A
IL-4 Th induce IgE
5
Q
What does IgE do in allergy?
A
interacts with Fce receptor
- immune mediators cause immediate rxn (histamine, lipid)
- cytokines (late-phase inflammation)
