Block 1 Lecture 3 -- Cells of the Immune System

Question 1

What is present in the granules of neutrophils?

Answer 1

specific granules = lysozyme+collagenase+elastase; azurophilic granules = defensins+cathelicidins

Question 2

What is present in the granules of basophils?

Answer 2

heparin + serotonin + histamine

Question 3

What is present in the granules of mast cells?

Answer 3

histamine, heparin

Question 4

What is present in the granules of eosinophils?

Answer 4

major basic protein (ABP) + cationic proteins

Question 5

What are macrophages present in the peritoneum called?

Answer 5

resident

Question 6

What are macrophages present in the lung called?

Answer 6

alveolar

Question 7

What are macrophages present in the kidney called?

Answer 7

intraglomerular mesangium

Question 8

What are macrophages present in the lymph nodes or spleen called?

Answer 8

sinusoidal

Question 9

What type of B cells are B1 cells?

Answer 9

innate

Question 10

What type of B cells are B2 cells?

Answer 10

memory

Question 11

What are the granulocytes?

Answer 11

neutrophils + eosinophils + basophils + mast cells

Question 12

What cells are phagocytes and APCs?

Answer 12

granulocytes + monocytes/macrophages/DCs

Question 13

What cells are polymorphonuclear cells?

Answer 13

granulocytes

Question 14

What cells are mononucelar cells?

Answer 14

lymphoids + monocytes/macrophages

Question 15

What are CD markers?

Answer 15

binding patterns of Abs often associated with stages of differentiation

Question 16

What are the types of Th cells?

Answer 16

Th1 + Th2 + Th17 + Th-follicular

Question 17

How are Th1 cells ID’d?

Answer 17

CD4+ IFN-gamma

Question 18

How are Th2 cells ID’d?

Answer 18

CD4+ IL-4

Question 19

How are Th17 cells ID’d?

Answer 19

CD4+ IL-17

Question 20

How are cytotoxic T’s ID’d?

Answer 20

CD8+

Question 21

How are gamma-delta T cells ID’d?

Answer 21

CD4-CD8-; gamma-delta T cell receptor

Question 22

Function of Th1 cells

Answer 22

cell-mediated immunity

Question 23

Function of Th2 cells

Answer 23

humoral immunity

Question 24

Function of Th17 cells

Answer 24

auto-immunity

Question 25

Function of Th follicular?

Answer 25

B cell development

Question 26

How are T lymphocytes ID'd?

Answer 26

CD3+

Question 27

Fx of neutrophils

Answer 27

phagocytosis; earliest and most robust responder; activate bactericidal mechanisms

Question 28

Fx of basophils

Answer 28

promote allergic response and augment anti-parisitic immunity thru presence in the blood

Question 29

Fx of mast cell

Answer 29

work as tissue-resident basophils for granule release

Question 30

Fx of eosinophils

Answer 30

kill Ab-coated parasites

Question 31

Fx of professional phagocytes/macrophages:

Answer 31

phagocytosis and APC; activation of bactericial mechanisms; wound repair

Question 32

Fx of APCs/DCs:

Answer 32

process and present Ag after migration to lymphocytes; T-cell activation

Question 33

What are the APCs:

Answer 33

major = DC; minor = macrophage, B

Question 34

Fx of NK cells

Answer 34

early recognition and destruction of viral infections and tumors; can kill via direct cytotoxicity after opsonization

Question 35

How are NK cells stimulated and what happens after?

Answer 35

stimulated by lipids; then produce IFN-gamma for Th1 response