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PHS 932 > Block 2 Lecture 5 -- Hypersensitivity and Immunodeficiency > Flashcards

Block 2 Lecture 5 -- Hypersensitivity and Immunodeficiency Flashcards

1
Q

What is the target Ag in autoimmune hemolytic anemia? What is the mechanism of disease?

A

erythrocyte membrane proteins (Rh)

– RBC opsonization

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2
Q

What is the target Ag in thrombocytopenic purpura? What is the mechanism of disease?

A

platelet membrane proteins

– platelet opsonization

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3
Q

What is the target Ag in pemphigus vulgaris? What is the mechanism of disease?

A

proteins in epidermal junctions

– Ab-mediated protease activation, adhesion disruption

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4
Q

What is the target Ag in Goodpasture’s syndrome? What is the mechanism of disease?

A

noncollagenous protein in kidney and lung

– complement- and Fc-mediated inflammation

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5
Q

What is the target Ag in acute rheumatic fever? What is the mechanism of disease?

A

Strep antigen

– inflammation and macrophage activation

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6
Q

What is the target Ag in myasthenia gravis? What is the mechanism of disease?

A

AchR

– inhibition of Ach binding

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7
Q

What is the target Ag in Graves’ disease? What is the mechanism of disease?

A

TSH receptor

– stimulation of TSH receptor

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8
Q

What is the target Ag in t2dm? What is the mechanism of disease?

A

insulin receptor

– insulin blockage

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9
Q

What is the target Ag in pernicious anemia? What is the mechanism of disease?

A

IF of gastric parietal cell

– dysfunctional IF

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10
Q

What is the clinical manifestation of autoimmune hemolytic anemia?

A

hemolysis, anemia

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11
Q

What is the clinical manifestation of thrombocytopenic purpura?

A

bleeding

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12
Q

What is the clinical manifestation of pemphigus vulgaris?

A

skin vesicles (bullae)

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13
Q

What is the clinical manifestation of goodpasture’s syndrome?

A

nephritis, lung hemorrhage

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14
Q

What is the clinical manifestation of acute rheumatic fever?

A

myocarditis, arthritis

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15
Q

What is the clinical manifestation of myasthenia gravis?

A

weak muscles and paralysis

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16
Q

What is the clinical manifestation of Graves disease?

A

hyperthyroidism

17
Q

What is the clinical manifestation of insulin-resistant diabetes?

A

hyperglycemia

18
Q

What is the clinical manifestation of pernicious anemia?

A

abnormal erythropoiesis, anemia

19
Q

What is the target Ag in vasculitis caused by ANCA? What is the mechanism of disease? What is the clinical manifestation?

A

neutrophil granule proteins

    • neutrophil degranulation and inflammation
    • nephritis and lung hemorrhage
20
Q

What is the target Ag in SLE?

A

DNA, nucleoproteins

21
Q

What is the target Ag in polyarteritis nodosa?

A

HBV surface Ag

22
Q

What is the target Ag in post-strep glomerulonephritis?

A

Strep wall ag

23
Q

What is the target Ag in serum sickness?

A

various proteins…?

24
Q

What is the clinical manifestation of SLE?

A

nephritis, arthritis, vasculitis

25
What is the clinical manifestation of polyarteritis nodosa?
vasculitis
26
What is the clinical manifestation of post-strep glomerulonephritis
nephritis
27
What is the clinical manifestation of serum sickness?
arthritis, vasculitis, nephritis
28
How might hypersensitivity be caused?
1) autoimmunity 2) reactions to microbes 3) reactions against environmental antigen
29
What is type I hypersensitivity?
Immediate, IgE-mediated
30
What is Type II hypersensitivity?
Ab-mediated | -- IgM + IgG against cell surface or extracellular matrix
31
What is Type III hypersensitivity?
Immune complex-mediated | -- circulating Abs and immune complexes of circulating Ags
32
What is the result of type I hypersensitivity?
degranulation of mast cells and mediators
33
What is the result of type II hypersensitivity?
- - opsonization - - phagocytosis - - complement - - cell function abnormalities
34
What is the result of type III hypersensitivity?
- - complement- and Fc-mediated leukocyte activation | - - clotting
35
What is type IV hypersensitivity?
T-cell-mediated | delayed type IV or T-cell-mediated cytolysis
36
What occurs in delayed type IV hypersensitivity?
CD4's activate macrophages, secrete cytokines = inflammation
37
What occurs in T-cell mediated cytolysis?
CD8's kill directly, secrete cytokines = inflammation
38
What diseases are due to type 4 delayed-type hypersensitivity?
- - t1dm - - MS - - RA - - Crohn's - - skin contact sensitivity
39
When does tissue damage begin in delayed-type hypersensitivity?
24-48 hours after initial response | damage due to products of macrophages

PHS 932 (23 decks)

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