Blood lecture 1 Flashcards

(57 cards)

1
Q

Cardiovascular system consists of

A

Heart, blood vessels, blood

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2
Q

Major function cardiovascular system

A

Deliver oxygen + nutrients

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3
Q

Hematology

A

study of blood,

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4
Q

Two fluids for transportation

A

Blood, interstitial fluid

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5
Q

Blood plasma

A

liquid connective tissue

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6
Q

Blood plasma composition

A

Water, plasma proteins, dissolved solutes

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7
Q

Blood transports what?

A

gases, nutrients, hormones, metabolic wastes

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8
Q

Blood regulates what?

A

pH, temperature, ion composition of IF

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9
Q

Functions of blood: protection

A

Restrict fluid loss
Defend toxins/pathogens

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10
Q

Avg. blood in adult

A

~5L

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11
Q

Whole blood =

A

blood w all components

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12
Q

2 major blood components

A

Plasma, formed elements

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13
Q

Plasma how much % of whole blood?

A

55%

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14
Q

Albumins % of plasma proteins

A

60%

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15
Q

Albumins function

A

Osmotic pressure

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16
Q

Globulins % of plasma proteins

A

35%

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17
Q

Antibodies (immunoglobins) function

A

attack foreign particles

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18
Q

Transport globulins functions

A

Bind ions, hormones, lipids

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19
Q

Fibrinogen % plasma proteins

A

~4%

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20
Q

Fibrinogen functions

A

blood clotting

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21
Q

Plasma solutes: Electrolytes

A

Essential for cellular activities

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22
Q

Plasma solutes: Organic nutrients

A

Cell ATP prod.

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23
Q

Plasma Solutes: Organic wastes

A

carried to breakdown or excretion sites

24
Q

Formed elements % of blood

25
% of formed elements RBC's make up
99%
26
Formed elements: Platelets %
<0.1%
27
Formed elements: WBC's %
<0.1%
28
Hematocrit
% of whole blood from formed elements
29
Lower hematocrit means
Anemia
30
Higher hematocrit means
Polycythemia
31
Hematopoiesis
How formed elements develop
32
RBC's lifespan
~120 days
33
Hematopoiesis begins where?
Yolk sac - embryonic development
34
Hematopoiesis switches where after yolk sac?
Liver, spleen, thymus
35
Last 3 months pregnancy hematopoiesis happens where?
red bone marrow
36
Red bone marrow produces?
RBC, WBC, platelets
37
Pluripotent stem cell derived from
mesenchyme
38
Pluripotent stem cells give rise to?
Lymphoid, myeloid
39
Lymphoid give rise to
lymphocytes, natural killer cells
40
Myeloid give rise to
neutrophils, monocytes, eosinophils, basophils, RBC, platelets
41
Progenitor cells known as
CFU - colony forming unit
42
Progenitor cells committed to give rise to
Specific elements of blood
43
CFU-E becomes
Erythrocytes
44
CFU-Meg becomes
Megakaryocytes -> platelets
45
CFU-GM becomes
Granulocytes
46
Precursor cells become
Actual blood cells
47
Optional step: RBC (slightly immature RBC name)
Reticulocyte (slightly immature RBC)
48
Optional step: Platelet precursor name
Megakaryocyte (platelet precursor)
49
Hemopoietic Growth Factors are what?
Hormones that regulate differentiation/proliferation of CFU's
50
EPO - Erythropoetin stimulates what? and released where?
RBC prod. // released kidneys
51
TPO - Thrombopoetin stimulates what? released where?
Prod. of thrombocytes // released liver
52
Cytokines stimulate what?
WBC prod.
53
Blood samples obtained via
venipuncture
54
m/c site for venipuncture
median cubital vein
55
Complete blood count determines
1 cubic ml of blood components
56
WBC differential count
Identify # of each WBC type
57
RBC tests can detect what?
Can detect internal bleeding