Bolded info for Nordgren drugs Flashcards Preview

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Flashcards in Bolded info for Nordgren drugs Deck (15):
1

Positive effects of Nitrates/trites on cardiac O2 consumption:

decrease LV EDP

decrease preload

2

NTG should not be given with which drugs due to synergistic hypotension:

phosphodiesterase type 5 inhibitors

Vardenafil (viagra, cialis, ect)

3

Positive effects (with respect to angina) of Ca2+ channel blockers on cardiac O2 consumption:

increased coronary blood flow

decreased aortic diastolic pressure

decreased HR

decreased contractility

4

Positive effects (with respect to angina) of Beta blockers on cardiac O2 demand:

decreased aortic diastolic pressure

decreased HR

decreased contractility

5

most common cause of angina?

atherosclerosis

6

Weak Beta blocker in Class IC?

Propafenone

7

Class IC with SLOW UNBLOCKING KINETICS?

Flecainide

8

Class IB with extra cardiac effect of significant chronic pain relief?

Mexiletine

9

Class IB used for Vtach

NOT ADVISED FOR PROPHYLAXIS

Lidocaine

10

Class IA

Loading dose NOT recommended

Disopyramide

11

Class IA

Toxicity = induction of TORSADES

Quinidine

12

Class IA

TORSADES + LUPUS-like syndrome

Procainamide

13

Why is "state dependance" useful in antiarrhythmics"?

Drugs bind preferentially to:
Activated (phase 0)
Inactivated (phase 2) channels

bind poorly to rested channels

so....work best in tachycardia (lots of activations and inactivations per unit time)
-significant loss of resting membrane potential (many inactivated channels

14

Normal LV end systolic volume (Wigger's):

60 mL

15

Normal LV end diastolic volume (Wigger's):

120 mL