Flashcards in CV micro Diebel Deck (16):
Non-tender, small hemorrhagic lesions on palms and soles?
Vascular phenomena--histology consistent with septic micro-emboli
type II hypersensitivity????
Red-purple, tender, papular, lesions usually on pads of fingers and toes?
type III hypersensitivity
Two pieces of Duke Criteria other than Osler's nodes and Janeway lesions:
Roth's spots (retinal hemorrhage????)
VF's for Strep viridans?
dextran--> glycocalyx formation
FimA, GspB --- surface adhesion proteins
subacute/chronic infectious endocarditis
VF for Strep pneumo?
capsule--- evades Ab response
VF for Strep pyogenes?
capsule --- evades Ab response
Streptokinase (converts plasminogen to plasmin)
M protein (resists phagocytosis)
Hyaluronidase (breaks down connective tissue)
DNase (digests DNA)
Streptolysin O (destroys RBCs)
Streptolysin S (destroys WBCs)
Streptokinase and hyaluronidase are encoded by a lysogenized prophage
S. aureus VF's:
elastin, collagen, fibronectin
VF for coxackie/adeno viruses:
CAR binding proteins
R. rickettsia VF's:
OmpA, OmpB --- attachment
Type 4 secretion system --- host cell entry
Dx test for RMSF?
tissue biospy--> PCR for R. rickettsii DNA
Classic triad for RMSF?
2. rash (extremities --> trunk)
Tx for RMSF?
MOA: inhibits binding of tRNA to 30s mRNA/ribosomal subunit
Pathogens causing similar rash to RMSF?
T. pallidum (syphillis)
Likely pathogens causing pericarditis?
Coxackievirus A or B
Differentiate between streptococcus species:
S. mutans (viridans, bovis):
-a-hemolytic--damage RBCs (looks green on augar)
-B-hemolytic -- destro RBCs (looks clear on augar)