CV micro Diebel Flashcards Preview

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Flashcards in CV micro Diebel Deck (16):
1

Non-tender, small hemorrhagic lesions on palms and soles?

Janeway lesions

Vascular phenomena--histology consistent with septic micro-emboli

type II hypersensitivity????

2

Red-purple, tender, papular, lesions usually on pads of fingers and toes?

Osler's nodes

Immunological phenomena

type III hypersensitivity

3

Two pieces of Duke Criteria other than Osler's nodes and Janeway lesions:

Rheumatoid factor

Roth's spots (retinal hemorrhage????)

4

VF's for Strep viridans?

Disease association?

dextran--> glycocalyx formation

FimA, GspB --- surface adhesion proteins

subacute/chronic infectious endocarditis

5

VF for Strep pneumo?

capsule--- evades Ab response

6

VF for Strep pyogenes?

capsule --- evades Ab response

Streptokinase (converts plasminogen to plasmin)

 M protein (resists phagocytosis)

 Hyaluronidase (breaks down connective tissue)

 DNase (digests DNA)

 Streptolysin O (destroys RBCs)

 Streptolysin S (destroys WBCs)

 Streptokinase and hyaluronidase are encoded by a lysogenized prophage

7

S. aureus VF's:

Capsule

biofilm formation

elastin, collagen, fibronectin

coagulase

leukocidin

8

VF for coxackie/adeno viruses:

CAR binding proteins

9

R. rickettsia VF's:

OmpA, OmpB --- attachment

Type 4 secretion system --- host cell entry

10

Dx test for RMSF?

tissue biospy--> PCR for R. rickettsii DNA

11

Classic triad for RMSF?

1. fever

2. rash (extremities --> trunk)

3. headache

12

Tx for RMSF?

Doxycycline

(tetracyclines)

MOA: inhibits binding of tRNA to 30s mRNA/ribosomal subunit

13

Pathogens causing similar rash to RMSF?

Coxackie virus

T. pallidum (syphillis)

14

Likely pathogens causing pericarditis?

Coxackievirus A or B

echovirus

15

Differentiate between streptococcus species:

S. mutans (viridans, bovis):
-a-hemolytic--damage RBCs (looks green on augar)
-bacitracin resistant

S. pyogenes
-B-hemolytic -- destro RBCs (looks clear on augar)
-bacitracin sensitive

16

Coxackie A and B

group:

genomic material:

envelope?

Group IV,

ssRNA+

nonsegment

nonenveloped

icosahedral