Trachte Adrenergic Agonists Flashcards Preview

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Flashcards in Trachte Adrenergic Agonists Deck (23):
1

Relate HR, TPR, SV and BP

BP = HR x SV x TPR

2

Stepwise synthesis of NE:

Tyrosine --> DOPA --> Dopamine --> NE --> Epi (in adrenal medula)

3

Cholinergic receptors in Heart and vessels:

Which nerve acts on them?

Muscarinic (M2)

Vagus (pre-ganglionic; Ach on Nicotinic R)

Parasympathetic

4

Adrenergic receptors on heart and vessels:

NT and R for ganglia synapse?

Beta1 (NE)-- Heart

alpha 1 (NE)-- vessels

Ach, Nicotinic

Sympathetic

5

Cholinergic receptors on sweat glands: NT?

M2, Ach

(ganglia is Ach, Nic)

Sympathetic

6

Sympathetic NT and receptor of renal vessels:

Dopamine, D1

(ganglia is Ach --> Nic)

7

NT's in the blood that act on Beta 1's and alpha 1's in the heart and vessels:

Where do they come from?

Epi

NE

Adrenal medula (sympathetic response via preganglionic neuron Ach on Nicotic R in the medula)

8

Inhibits axoplasmic pump to potentiate sympathetic response:

Cocaine

9

Inhibits granular pump accumulating catecholamines in vesicles (results in depletion of catecholamines):

Respirine

10

Induces release of NE from vesicles --> depletes NE stores --> reduces response to sympathetic stimulation

**inactive in the presence of MOA inhibitors like Pargyline

Guanethidine

11

Two enzymes that degrade adrenergic amines:

COMT (cytoplasm)

MAO (mitochondria)

12

MAO inhibitor:

Patients taking this should avoid what?

pargyline

foods high in tyramine

13

a1 receptor

primary CV location:

relative response to NT's:

MOA:

blood vessels

epi >/= NE >> isoproterenol

activates phospholipase C (Gq protein rec.) --> inc. intracellular Ca2+ via IP3

**mediates smooth muscle CONTRACTION

14

Beta 1 receptor

locations:

relative response to NTs:

MOA:

adrenergic cardiac effects, renin release

heart, JG apparatus and adipose tissue

isoproterenol > epi = NE

acts to increase cAMP via Gs

15

Beta 2 receptor

locations:

relative response to NTs:

MOA:

relaxation of smooth muscle and glycogenolytic effects

vascular smooth muscle

isoproterenol > epinephrine >> NE

increase cAMP via Gs

16

Selective B1 agonist

positive inotrope (increases muscular cont.)

Dobutamine

17

-positive inotrope at B1
-vasodilator in renal and mesentary at low doses (dopaminergic)
-vasoconstrictor at a1 at high doses

used in shock (maintains renal perfusion) and hypotension (inc. BP and CO)

Dopamine

18

a1 agonist

used to reverse hypotension or treat paroxysmal atrial tachycardia

also used as mydriatic and topical vasoconstrictor

Phenylepherine

19

B2 selective agonists used for bronchodilation (3):

Metaproterenol

Albuterol

Salmeterol

20

B2 selective agonists used to delay labor (2):

ritodrine

terbutaline

21

vasodilates at B2

tachycardia at B1

metabolised by COMT but not MAO

synthetic catecholamine

Isoproterenol

22

Vasoconstricts at a1

increases HR and force at B1

used to treat hypotension

Norepinephrine

23

Vasoconstricts a1

vasodilates B2

inc. HR

used in anaphylaxis to treat bronchospasm and hypotension

Epinephrine