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CRRAB 1 > Final all Drugs > Flashcards

Final all Drugs Flashcards

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1
Q

Peroxisome proliferator-activated receptor-a (PPAR-a) agonists

Upregulate apo A-I, A-II
Downregulate apo C-III

lowers LDL

increases HDL

A

Gemfibrozal

Fenofibrate

“fibrates”

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2
Q

HMGcoA reductase inhibitors

upregulate hepatocyte LDL receptors

decrease triglycerides

A

statins

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3
Q

Decreases catabolism of apo AI and reduces VLDL secretion

A

Niacin

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4
Q

Binds bile acids in gut –> excretion

Liver takes more cholesterol out of circulation to make more bile

lower LDL

A

Colestipol

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5
Q

Blocks sterol transporter NPC1L1 in intestine brush border

decreases cholesterol absorbed

lower LDL

A

Ezetimibe

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6
Q

irreversible COX I and II inhibitor. Stops the synthesis of thromboxane, which is responsible for platelet activation.

A

aspirin

***Baby ASA preferentially inhibits TXA production, leading to an overall vasodilatory effect (PGI2 is vasodilatory and is not inhibited at 81mg dose).

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7
Q

o MOA: activation of K+ channels and inhibition of L-type Ca2+ channels

Used for converting SVT

A

Adenosine

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8
Q

 Inhibits Na+/K+/ATPase pump

reverses NCX pump –> increased intracellular Ca2+

increased contractility, SV, CO

decreased HR

A

Digoxin

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9
Q

selective peripheral vascular Ca2+ blockers

relax VSM

risk of reflex tachycardia

A

dihydropyridines

”—pine”

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10
Q

selective myocardial Ca2+ blocker

reduce mycordial O2 demand

Tx: angina, arrhythmias

A

Verapamil

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11
Q

blocks both VSM and myocardial Ca2+ channels

A

Diltiazem

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12
Q

Binds P.B.P. and blocks transpeptidation of

peptidoglycan in bacterial cell walls.

A

Ceftriaxone

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13
Q

Binds D-ala-D-alanine to prevent NAM/NAG-peptide subunits into peptidoglycan. BLOCKS TRANSGLYCOSYLATION

A

Vancomycin

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14
Q

Beta-Lactam: Binds P.B.P. and blocks transpeptidation of

peptidoglycan in bacterial cell walls.

A

Penicillin G

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15
Q

AMINO-Beta-Lactam: Binds P.B.P. and blocks transpeptidation of peptidoglycan in bacterial cell walls.

A

Amoxicilin

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16
Q

Converts plasminogen to plasmin thus increasing breakdown of fibrin clots

A

t-PA

Alteplase

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17
Q

Acts on mu receptors in three locations

analgesic

A

Morphine

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18
Q

Forms free radical NO

A

Nitroglycerin

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19
Q

Blocks ADP receptors on platelets

inhibits platelet activation

A

Clopidogrel

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20
Q

increases Activity of antithrombin III

A

Heparin

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21
Q

Binds GPIIb/IIIa receptor on activated platelets

inhibits binding of fibrinogen

A

Eptifibitide

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22
Q

Suppresses RAAS system by inhibiting conversion of Angiotensin I to Angiotensin II.

A

lisinopril

enalapril

ACE inhibitors

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23
Q

Same mechanism as nitroglycerine – longer half life

A

isosorbide dinitrate

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24
Q

Increases NO synthesis in endothelium.

A

Hydralazine

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25
Inhibits NKCC2 diuretic
Furosamide
26
Blocks aldosterone action. Diuretic
Spirinolactone Eplerenone
27
Alteplase
thrombolytic plaminogen --> plasmin
28
NTG
vasodilator
29
Clopidogrel
anti-coagulant blocks ADP receptors
30
heparin
anti-coagulant activates anti-thrombin III
31
Eptifibitide
anti-coagulant binds GIIb-IIIa
32
Lisinopril
ACE inhibitor
33
Enalapril
ACE inhibitor
34
-statins
HMG-CoA reductase inhibitors decrease LDL
35
Metoprolol
selective B-1 blocker
36
Propanolol
non-selective Beta blocker
37
Isosorbide dinitrate
long acting nitro vasodilation
38
Hydralazine
increases NO more effect on ARTERIOLES
39
furosamide
diuretic inhibits NKCC pump
40
eplerenone
angiotensin receptor blocker (ARB)
41
spironolactone
ARB
42
Digoxin
Na+/K+/ATPase pump inhibitor increased intracellular Ca2+ --> inc. contractility decreased HR
43
cocaine
blocks NE reuptake axoplasmic pump
44
Imipramine
blocks NE reuptake axoplasmic pump
45
Reserpine
inhibits accumulation of catecholamines in vesicles
46
Guanethidine
releases NE from vesicles --> degraded by MAO
47
pargyline
MAO inhibitor
48
tyramine
releases catecholamines cheese, wine, beer
49
dobutamine
selective B-1 agonist positive inotrope used in CHF/MI with HF
50
dopamine
positive inotrope at B-1 vasodilation in renal and mesenteric vessels at low dose a1 agonist at high dose used in shock
51
phenylephrine
a1 agonist
52
metaproterenol
B-2 selective agonist bronchodilation
53
terbutaline
B-2 selective agonist delays labor
54
albuterol
selective B-2 agonist bronchodilation
55
ritodrine
selective B-2 agonist delays labor
56
salmeterol
selective B-2 agonist bronchodilation
57
isoproterenol
non-selective Beta agonist vasodilates at B-2 tachycardia at B-1
58
norepinephrine
vasoconstricts at a1 increased HR at B-1
59
epinephrine
vasoconstricts at a1 bronchodilation at B-2 increased HR at B-1
60
terazosin
a1 blocker
61
amphetamine
releases NE from nerves
62
ephedrine
releases NE indirect activation of a1, B1 also vasodilates at B2 (direct effect)
63
pseudoephedrine
similar to ephedrine
64
guanadrel
releases NE from vesicles for degradation by MAO
65
procaiamide
Class IA slows upstroke of AP (Na+ blocker), prolongs ERP (non-specific K+ blockade) can cause: torsades lupus
66
quinidine
Class IA has anti-muscarinic (anti-PNS) effects can cause: torsades
67
disopyramide
Class IA NO loading doses --> precipitates HF
68
Lidocaine
Class IB treats Vtach and Vfib after cardioversion NO prophlaxis
69
mexiletine
Class IB oral version of lidocaine chronic pain too
70
Tocainide
Class IB lidocaine analog
71
flecainide
Class IC slow unblocking kinetics (but does not prolong AP or QT)
72
propafenone
Class IC weak Beta blocker
73
moricizine
Class IC not sold in US so prob not on test
74
propanolol
non-selective Beta blocker don't give if asthma (B2 block--> bronch spasm) treats SVT w/o AV blocks (can exacerbate)
75
Acebutolol
non-selective Beta blocker treats HTN and SVTs
76
esmolol
short acting, selective B-1 blocker
77
sotalol
Beta blocker at low dose K+ antiarrhythmic at high dose
78
enoxaparin
low molecular weight heparin
79
amiodarone
Class III (and I, II, IV) treats Vtach, Vfib, Afib, Aflutter PULM toxicity LOOONG half life iodine buildup
80
dofetilide
Class III very selective K+ blocker Contraindicated in long QT, bradycardia, hypokalemia
81
ibutilide
Class III K+ blocker and slow inward Na+ ACTIVATOR
82
dihydropyridines
Class IV smooth muscle Ca2+ channel selective **reflex tachycardia, don't use in angina
83
verapimil
Class IV cardio selective Ca2+ blocker--preference for frequently firing tissue treats angina and arrhythmia reduces myocardial O2 demand don't use in WPW!!!
84
Diltiazem
Class IV BOTH cardiac depressant and vasodilatory no reflex tachycardia
85
adenosine
activates K+ inhibits Ca2+ hyperpolarization and suppression of Ca2+ dependent APs (SA and AV tissue) used for SVTs don't use in 2 and 3 AV block
86
nifedipine
Class IV dihydropyridine vaso seletive Ca2+ blockage used in angina also HTN
87
gemfibrozil
PPAR-a agonist decreases VLDL secretion
88
fenofibrate
PPAR-a agonist decreases VLDL secretion
89
niacin
Blocks adipocyte lipolysis. Decreases catabolism of apo AI and reduces VLDL secretion.
90
colestipol
binds bile acid
91
ezetimibe
Blocks sterol transporter NPC1L1 in intestinal brush border

CRRAB 1 (17 decks)

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