Bone, Soft Tissue

Question 1

Bone tumor associated with McCune Albright syndrome (polyostic FD, cafe-au-lait spots, endocrine abnormalities?

Answer 1

Fibrous Dysplasia — Chinese characters
no osteoblastic rimming

Question 2

Radiographic result of Osteosarcoma:

Answer 2

Codman triangle (perisoteal lifting
sunburst appearance (infiltrative disorders)
lytic and blastic lesion

Question 3

Bone tumor of Hyaline cartilage that occurs in bones of endochondral origin

Answer 3

Chondroma
loc: metaphysis
Assoc: Ollier and Maffuci syndrome

Question 4

Micro: Small round blue cells and Homer Wright rosette
Radio: lytic lesion, Periosteal reaction: Onion-skin
Diaphysis located

Answer 4

Ewing Sarcoma
2nd MC group of bone sarcomas in children
mutation in t(11;22) EWSR1-FLI1

Question 5

Avascular necrosis of ossification center in children

Answer 5

Legg-Calve Perthes Disease

Question 6

MC causative agent of Osteomyelitis

Answer 6

S. aureas (MC)
GUT infection: E,coli, Pseudomonas, Klebseilla
Neonates: H. influenza, GBS
Sickle Cell Dse: Salmonella

Question 7

MC skeletal Dysplasia
major cause of DWARFISM

Answer 7

Achondroplasia
AD, mutation in FGF3 (inhibition of endochondral growth)

Question 8

MC lethal form of dwarfism

Answer 8

Thantophoric Dysplasia
usual death: Respiratory insufficiency

Question 9

MC inherited disorder of the Connective tissue
extreme skeletal fragility due to little bone

Answer 9

Osteogenesis imperfecta/Brittle bone dse
Blue sclerae
type I collagen, AD

Question 10

morpho: Absence of medullary canal and Erlenmeyer Flask deformity

Answer 10

Osteopetrosis/ Marble bone disease
impaired osteoclast function
most AR
Mild autosomal dominant: Albers-Schonberg disease

Question 11

Presence of jigsaw puzzle due to cement lines
mosaic pattern of lamellar bone
elderly, bone pain

Answer 11

Paget Disease/ Osteitis Deformans

Question 12

Bouchard node
Heberden nodes
Osteophytes (Bone spurs)

Answer 12

Osteoarthritis
Bouchard node – PIP
Heberden node - DIP
No systemic sx
primarily weight bearing joint

Question 13

Triad of Felty Sydrome seen in RA

Answer 13

RA
splenomegaly
Neutropenia

Question 14

Skeletal changes in chronic renal failure:
Osteopenia
Osteomalacia
Secondary hyperparathyroidism
Growth retardation

Answer 14

Renal Osteodystrophy

Question 15

most dreaded complication of Pagets dse

Answer 15

Osteosarcoma
Fibrosarcoma

Question 16

fracture healing:
Soft tissue callus/Procallus formation
not yet good for weigh bearing

Answer 16

0-2 weeks

Question 17

fracture healing:
Bony callus (Woven bone)

Answer 17

2-3 weeks
inc progenitor cells

Question 18

fracture healing:
Lamellar bone

Answer 18

3wks - months

Question 19

younger patient’s bone tumor most likely are BENIGN, except

Answer 19

Osteosarcoma
Ewing Sarcoma

Question 20

<2cm
Appendicular skeleton - MC: femur
Pain relived by NSAIDs
marked reactive bone formation

Answer 20

Osteoid Osteoma
tx: Radiofrequency ablation

Question 21

> 2cm
Axial skeleton
non responsive to NSAIDs

Answer 21

Osteoblastoma
tx: En bloc excision

Question 22

<20 y/o
Metaphysis
Codmann triangle
Sunburst appearance
lace-like pattern bone formation

Answer 22

Osteosarcoma

Question 23

Bone lesion located in METAPHYSIS

Answer 23

Osteosarcoma
Osteochondroma
Chondroma

Question 24

Bone lesion located in EPIPHYSIS

Answer 24

Giant cell tumor

Question 25

Bone lesion located in DIAPHYSIS

Answer 25

Ewing sarcoma

Question 26

Bone lesion located in AXIAL skeleton

Answer 26

Chondrosarcoma Osteoblastoma

Question 27

MC benign bone tumor Metaphyseal location

Answer 27

Osteochondroma solitary loca: knee

Question 28

Spindle hemangiomas and brain gliomas

Answer 28

Maffuci syndrome Seen in Chondroma

Question 29

tumor cells have inc RANKL levels -- inc bone resoprtion Epiphysis located 3rd-5th decade benign, locally aggressive

Answer 29

Giant cell tumor bone/ Osteoclastoma

Question 30

Polyostotic FD + Cafe-au-lait spots + Precocious puberty

Answer 30

McCune Albright syndrome

Question 31

Polyostotic FD + Soft tissue myxoma

Answer 31

Mazabraud syndrome

Question 32

MC skeletal malignancy

Answer 32

Metastasis

Question 33

Autoimmunity, CD4+ T cells and antibodies small joints of the fingers + Pannus severe chronic inflammation Swan Neck deformity Buotonniere deformity

Answer 33

Rheumatoid Arthritis Swan Neck deformity - PIP hyperextension, DIP flexion Buotonniere deformity - PIP flexion, DIP hyperextension

Question 34

HM of gout

Answer 34

Tophi aggregate of urate crystals surrounded by foreign body giant cells

Question 35

Hyperuricemia monoarticular joint 1st MTP of big toe Monosodium urate, needle shape negatively birefringent (yellow)

Answer 35

Gout

Question 36

Pseudogout contents

Answer 36

Calcium Pyrophosphate dihydrate Rhomboid, + birefringent (blue) Mono/polyarticular MC involve: knee

Question 37

MC Soft tissue tumor of adulthood

Answer 37

Lipoma encapsulated mass of mature adipocytes

Question 38

MC sarcoma of adulthood

Answer 38

Liposarcoma + lipoblast

Question 39

mutation in t(12;16) myxoid with chicken wire vessel scattered round cells and lipoblast

Answer 39

Myxoid Liposarcoma