Bones

Question 1

Alendronic acid renal cut off

Answer 1

eGFR below 35

Question 2

Risedronate Renal cut off

Answer 2

egfr below 30

Question 3

How many minutes to take alendronic or risedronate before breakfast

Answer 3

30 minuts

Question 4

How long must you stand/ upright after taking alendronic or risedronate

Answer 4

30 minutes

Question 5

Drugs that contribute to bone fractures

Answer 5

Pioglitazone
SSRI
PPI
Carbamazepine
Goserelin
Aromatase inhibitors (letrozole)

Question 6

Alendronic acid doses

Answer 6

Treatment of postmenopausal OP- 10mg daily/ 70mg once a week

OP in men - 10mg daily

Question 7

Risedronate doses

Answer 7

Postmenopausal OP- 5mg daily/ 35mg once weekly

OP in men - 35mg once weekly

Question 8

Bisphosphonates safety alerts MHRA

Answer 8

Osteonecrosis of the jaw
Osteonecrosis of ear canal
Atypical femoral fractures (associated with Long term treatment)

Question 9

Bisphosphonates monitoring

Answer 9

Hypocalcaemia and vitamin d needs to be corrected before treatment

Question 10

Bisphosphonate interactions

Answer 10

Calcium- Take at least 30 mins before alendronic acid
NSAIDS- may increase GI irritation

Question 11

How much water to drink for dose with bisphosphonates

Answer 11

200ml

Question 12

Why sit upright, empty stomach and 200ml

Answer 12

These steps help prevent oesophageal irritation and ensure proper absorption