Thyroid Flashcards
(7 cards)
Carbimazole and pancreatitis
Carbimazole can cause neutropenia. It should not be used in patients with a history of acute pancreatitis
associated with previous treatment. Re-exposure may result in life threatening acute pancreatitis with a
decreased time to onset. The other drugs listed, do not cause neutropenia and/or pancreatitis.
Carbimazole and contraception
MHRA advises all females of child bearing age should use effective contraception during treatment
Carbimazole interaction
Increased risk with other drugs that also cause myelosuppresion like bleomycin, mTX, Mercaptopurine, Trimethoprim, sulfasalazine
Propylthiouracil CI
Severe hepatic impairment
Propylthiouracil cautions
use half dose if renal function is below 10 and 75% if between 10-50
Propylthiouracil in pregnancy
Can be given in pregnancy but the blocking replacement regimen is not suitable. Can cross the placenta and in high doses can cause fetal goitre and hypothyroidism
Propylthiouracil counselling
Bone marrow suppression
Liver disorders