Thyroid Flashcards

(7 cards)

1
Q

Carbimazole and pancreatitis

A

Carbimazole can cause neutropenia. It should not be used in patients with a history of acute pancreatitis
associated with previous treatment. Re-exposure may result in life threatening acute pancreatitis with a
decreased time to onset. The other drugs listed, do not cause neutropenia and/or pancreatitis.

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2
Q

Carbimazole and contraception

A

MHRA advises all females of child bearing age should use effective contraception during treatment

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3
Q

Carbimazole interaction

A

Increased risk with other drugs that also cause myelosuppresion like bleomycin, mTX, Mercaptopurine, Trimethoprim, sulfasalazine

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4
Q

Propylthiouracil CI

A

Severe hepatic impairment

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5
Q

Propylthiouracil cautions

A

use half dose if renal function is below 10 and 75% if between 10-50

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6
Q

Propylthiouracil in pregnancy

A

Can be given in pregnancy but the blocking replacement regimen is not suitable. Can cross the placenta and in high doses can cause fetal goitre and hypothyroidism

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7
Q

Propylthiouracil counselling

A

Bone marrow suppression
Liver disorders

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