SGLT2 inhibitors Flashcards
(3 cards)
1
Q
SGLT2 MOA
A
The sodium glucose co transporter 2 is present in the proximal tubules of the kidney and reabsorbs filtered glucose from the renal tubular lumen. This process is inhibited which results in reduced reabsorption of filtered glucose into the body and lowers the renal threshold for glucose resulting in increased urine glucose excretion
2
Q
SGLT2 inhibitors SE
A
Constipation
Thirst
Nausea
Lower UTI
Hypoglycaemia
Polyuria
3
Q
SGLT2 MHRA
A
DKA- potentially life threatening - discontinue if symptoms occur
Increase risk of Lower limb amputations (toes) - cannaglifozin may increase the risk of lower limb amputations
