Pioglitazone

Question 1

Pioglitazone MOA

Answer 1

Reduces peripheral insulin resistance leading to a reduction of blood glucose

Question 2

Pioglitazone SE

Answer 2

GI disruption
Weight Gain
Hypoglycaemia
Haematuria
Liver toxicity

Stop if liver toxicity (GI discomfort, tiredness, jaundice, dark urine)

Question 3

MHRA PIOGLITAZONE

Answer 3

Risk of HF (increases with insulin use)
Increased risk of bladder cancer (stop if haematuria, pyuria or urinary urgency)

Question 4

Pioglitazone cautions

Answer 4

Concurrent use of insulin (increased risk of HF)

Elderly (increased risk of HF, Bladder cancer, fractures)

Increased risk of bone fractures in women

Question 5

Pioglitazone and liver toxicity

Answer 5

Stop if experiencing nausea, vomiting, stomach discomfort, exhaustion or dark urine