DPP-4 inhibitors

Question 1

DPP-4 inhibitors MOA

Answer 1

Inhibits the DPP4 enzymes that break down incretins. Incretins are hormones produced by the gut in response to food that stimulate insulin secretion and decrease glucagon secretion

Question 2

DPP-4 inhibitors SE

Answer 2

Hypoglycaemia
GI upset
Peripheral odema

PANCREATITIS
LIVER TOXICITY

Question 3

Which DPP-4 inhibitor does not need a dose reduction in renal impairment

Answer 3

Linagliptin

Question 4

Are DPP-4 inhibitors weight neutral

Answer 4

Yes

Question 5

DPP-4 niche side effect

Answer 5

CAN CAUSE RESPIRATORY TRACT infections and nasopharyngitis