C5 - How do we fuel our body? Flashcards

(67 cards)

1
Q

What are the ways that ions and molecules can pass through the cell membrane?

A

Ions and molecules can pass through the cell membrane via:

  • Passive transport
  • Active transport
  • Osmosis
  • Facilitated diffusion

Passive transport does not require energy, while active transport requires energy.

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2
Q

What is osmosis?

A

Osmosis is the diffusion of water across a selectively permeable membrane, determined by the concentration gradient of solutes.

Water moves from a solution with high free water concentration to one with low free water concentration.

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3
Q

Define hypotonic, isotonic, and hypertonic solutions.

A

Definitions:

  • Hypotonic: Less solutes and more water than the inside of the cell
  • Isotonic: Same total concentration of solutes as intracellular fluid
  • Hypertonic: More solutes and less water than the inside of the cell

These terms describe the relative concentrations of solutes in solutions.

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4
Q

What are ATP and ADP in terms of energy?

A

ATP (adenosine triphosphate) is the primary energy carrier in cells, while ADP (adenosine diphosphate) is formed when ATP releases energy.

The conversion between ATP and ADP is central to energy transfer in cellular processes.

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5
Q

List the main stages of glycolysis.

A

The main stages of glycolysis include:

  • Energy investment phase
  • Cleavage phase
  • Energy payoff phase

The products of glycolysis include pyruvate, ATP, and NADH.

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6
Q

Describe the main stages of the citric acid cycle (Krebs cycle).

A

The main stages of the citric acid cycle include:

  • Acetyl-CoA formation
  • Citrate formation
  • Isomerization
  • Oxidative decarboxylation
  • Regeneration of oxaloacetate

The products of the citric acid cycle include NADH, FADH2, ATP, and CO2.

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7
Q

What is oxidative phosphorylation?

A

Oxidative phosphorylation is the process by which ATP is produced via the electron transport chain and chemiosmosis.

This process occurs in the mitochondria and is a key stage of cellular respiration.

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8
Q

Why can some things pass through a cell membrane whereas others can’t?

A

Some substances can pass through a cell membrane due to its selectively permeable nature, which allows certain molecules to cross while preventing others.

This selectivity is influenced by factors such as size, polarity, and charge of the molecules.

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9
Q

How do ions and molecules pass through the cell membrane?

A

Ions and molecules pass through the cell membrane via:

  • Passive transport (diffusion)
  • Active transport (requiring energy)
  • Facilitated diffusion (with the help of proteins)

The method of transport depends on the type of molecule and its concentration gradient.

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10
Q

Why does water move from one place to another within the body?

A

Water moves based on osmotic gradients, where it travels from areas of low solute concentration to areas of high solute concentration.

This movement is essential for maintaining homeostasis in body fluids.

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11
Q

What is the fluid mosaic model of cell membranes?

A

The fluid mosaic model describes the cell membrane as a dynamic structure with a flexible arrangement of phospholipids and proteins that can change shape and composition.

This model emphasizes the fluidity of the membrane and the diverse functions of membrane proteins.

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12
Q

What does it mean that the cell membrane is selectively permeable?

A

Being selectively permeable means that the cell membrane allows certain substances to pass while restricting others.

This property is crucial for maintaining the internal environment of the cell.

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13
Q

Define diffusion.

A

Diffusion is the passive movement of solute molecules from a region of high concentration to a region of low concentration.

This process does not require energy and is influenced by concentration gradients.

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14
Q

What is facilitated diffusion?

A

Facilitated diffusion is a passive transport process that uses membrane proteins to help molecules cross the cell membrane.

It does not require energy and is critical for transporting larger or polar molecules.

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15
Q

What is the sodium-potassium pump?

A

The sodium-potassium pump is an example of active transport that moves sodium ions out of the cell and potassium ions into the cell against their concentration gradients.

This pump is essential for maintaining cellular homeostasis and membrane potential.

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16
Q

What happens to water movement in a hypertonic solution?

A

In a hypertonic solution, water moves out of the cell, leading to cell shrinkage.

This occurs because the concentration of solutes outside the cell is higher than inside, creating a concentration gradient.

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17
Q

What happens to water movement in a hypotonic solution?

A

In a hypotonic solution, water moves into the cell, which can lead to cell swelling or bursting.

This occurs because the concentration of solutes inside the cell is higher than outside, creating a concentration gradient.

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18
Q

Define diffusion

A

Movement of solute molecules passively from high concentration to low concentration

There is net movement of molecules down their concentration gradient.

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19
Q

What is facilitated diffusion?

A

A passive process that uses carrier/channel proteins to help molecules cross the cell membrane

It moves down the concentration gradient, similar to simple diffusion.

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20
Q

Is facilitated diffusion an active process?

A

No, it is a passive process.

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21
Q

Give an example of a substance that crosses the membrane via facilitated diffusion.

A

Glucose

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22
Q

What is the process by which water crosses the cell membrane?

A

Osmosis

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23
Q

What are the channels used by water to cross the cell membrane?

A

Aquaporins

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24
Q

When is active transport required?

A

When a solute moves up its concentration gradient

This means moving from low to high solute concentration.

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25
Does active transport use cellular energy?
Yes, it requires energy (ATP).
26
Give an example of two substances moved via active transport.
Na+ and K+ ## Footnote Na+ is pumped out of cells, K+ is pumped into cells.
27
What are the Na+ and K+ concentrations on either side of the membrane?
Na+: ~140 mmol/L extracellular, ~10 mmol/L intracellular; K+: ~150 mmol/L intracellular, ~4 mmol/L extracellular
28
What is cellular respiration?
The process of breaking down glucose into CO2 and H2O to produce energy.
29
What is the overall equation for cellular respiration?
C6H12O6 + 6O2 → 6CO2 + 6H2O + 36-38 ATP
30
What are the three stages of cellular respiration?
* Glycolysis * Citric acid cycle * Oxidative phosphorylation
31
Where does glycolysis occur?
In the cytoplasm
32
What is produced at the end of glycolysis?
2 x ATP, 2 x NADH, 2 x pyruvate
33
What is the net production of ATP in glycolysis?
2 x ATP
34
What happens to pyruvate if no oxygen is available?
It gets converted to lactic acid.
35
Where does the citric acid cycle occur?
In the matrix of the mitochondria.
36
What is formed from the conversion of pyruvate to acetyl CoA?
1 x NADH and 1 x CO2
37
What is produced in one turn of the citric acid cycle?
* 1 x ATP * 3 x NADH * 1 x FADH2
38
How many ATP are produced from the citric acid cycle for one glucose molecule?
2 x ATP
39
What is oxidative phosphorylation?
The process where energy from electron movement is used to synthesize ATP.
40
What are the by-products of oxidative phosphorylation?
Water (H2O)
41
How much ATP is produced during oxidative phosphorylation?
32-34 ATP
42
What is the total ATP yield from one molecule of glucose?
Approximately 36-38 ATP
43
What does glycolysis mean?
Breakdown of glucose
44
What is the first step of cellular respiration?
Glycolysis
45
What is the preferred carbohydrate for cellular energy?
Glucose
46
What does ATP stand for?
Adenosine triphosphate
47
What is the effect of an isotonic solution on a cell?
No net movement of water
48
What happens to a cell in a hypertonic solution?
It shrinks/crenates
49
What happens to a cell in a hypotonic solution?
It swells and may burst
50
True or False: Water moves towards a higher solute concentration.
True
51
True or false: water will move in the direction of a higher solute concentration.
True. A solution with a higher solute concentration has a lower concentration of water molecules, so water moves towards the lower concentration of water molecules to try and even things up.
52
What is meant when we say a solution is isotonic?
An isotonic solution has the same tonicity (solute concentration) as the cell cytoplasm, resulting in no NET movement of water into or out of the cell.
53
What is the osmolarity of an isotonic solution?
290 mOsm.
54
Which test tube in Figure 5.4 is isotonic and why?
Test tube 2 is isotonic because the number of solute particles inside the cell and outside the cell is the same.
55
What is Cystic Fibrosis (CF)?
Cystic Fibrosis is the most common, life-shortening chronic illness affecting young Australians, primarily affecting the lungs and digestive system.
56
What causes Cystic Fibrosis?
It is caused by the abnormal transport of water, chloride, and sodium across the cell membranes of epithelial cells.
57
What is the role of the CFTR channel protein?
The CFTR channel protein moves chloride ions out of an epithelial cell to the covering mucus.
58
What follows chloride ions out of the cell to maintain balance?
Positively charged sodium ions.
59
What happens when the CFTR channel protein is faulty?
Ions do not pass out of the cell, leading to thick sticky mucus secretions that block various tubes and passageways in the body.
60
What are some symptoms of Cystic Fibrosis in young children?
Bowel obstruction, frequent chest infections, and coughing.
61
What is a consequence of thick mucus in the lungs for children with CF?
It inhibits gas exchange.
62
What is the average life expectancy for Australians with CF today?
38 years.
63
True or false: one in every 25 Australians carries a defective CF gene.
True.
64
Fill in the blank: Major advances in medical research have made Cystic Fibrosis much more _______.
manageable.
65
What has improved the survival rate for children with CF?
Major advances in medical research, such as lung transplants.
66
What must children with CF do as they grow to release mucus?
They must cough and exercise.
67
What is a common complication of CF patients due to thick mucus?
Bacterial infections in the lungs and airways.