Canine Estrus Control/Drug Therapy Flashcards Preview

RUSVM Theriogenology > Canine Estrus Control/Drug Therapy > Flashcards

Flashcards in Canine Estrus Control/Drug Therapy Deck (19):
1

Why is Megestrol Acetate (Ovaban®) contraindicated in the queen?

causes diabetes mellitus

2

T/F: In order to be effective, Megestrol Acetate (Ovaban®) must be used within the first three days of estrus

False

  • In order to be effective, Ovaban® must be used within the first three days of proestrus
  • Next estrus cycle will be 4-6 weeks earlier

3

T/F: Use of Depo-Provera® may predispose bitches to CEH and pyometra

True

Medroxyprogesterone acetate (MPA), commonly known as Provera ® or Depo-Provera®, is used to suppress the heat cycle in female dogs

4

In the bitch, progesterone needs to be in a range of ___ ng/mL or lower to consider supplementing

In the bitch, progesterone needs to be in a range of 3 ng/mL or lower to consider supplementing

5

If you're going to supplement progesterone in a pregnant bitch, you should ideally wait until 45 days of pregnancy or (at a minimum) avoid the first trimester (21 days). Why?

to avoid masculinization of female pups or maintain a physiologic concentration of P4

Remove Progesterone 2 to 3 days prior to due date to allow cervix to relax adequately. Any progestagen can masculinize the female fetuses

6

T/F: Progesterone supplementation during pregnancy can feminize male fetuses

False

Progesterone supplementation during pregnancy can masculinize female fetuses

7

What does Mibolerone (Cheque®) do?

prolongs interestrus interval (IEI)

prevents LH release by negative feedback, thereby preventing estrus

  • Androgenic compound
  • Not approved for use in breeding bitches
  • Generally not recommended due to safety/efficacy issues

8

Deslorelin is a(n) ______ analogue. It down-regulates the pituitary-gonadal axis

Deslorelin is a GnRH analogue. It down-regulates the pituitary-gonadal axis

  • It can be used for long or short term suppression of reproductive function of dogs and in situations where a reduced Testosterone level is required, such as controlling antisocial behavior and treating prostatic enlargement
  • Approved in ferrets

9

"Mismating" shots can be given to cause "tubular lockage" and disrupt/alter the uterine environment. They must be given within ____ hours of breeding to be effective

72 hours

  • Estrogen - within 72 hours of breeding - while still in estrus
    • Take cytology to confirm estrus/sperm
  • Causes “tubular lockage” and disrupts/alters uterine environment
  • 25% incidence of pyometra - side effect
  • Only ~38% of dogs become pregnant from one mating – so may want to delay drugs until ~30 day ultrasound

10

What is the main sign of estrogen toxicity seen in dogs and ferrets?

bone marrow suppression/aplasia

11

T/F: Mismating shots must be administered within 63 days of breeding

False

Mismating shots must be administered within 72 hours of breeding

12

T/F: Multiple small injections of prostaglandin will lyse the CL of the bitch or the queen

True

  • Side effects seen with smooth muscle contractions but minimize over time
    • Luteolytic dose only 5 fold from the LD 50
  • May get drop in blood pressure (some need IV fluids to stabilize), vomiting, diarrhea, salivation and panting
  • Used for treatment of pyometra, retained placenta, mismating, collection of males
    • Best accomplished during 2nd trimester after pregnancy diagnosis

13

Bromocriptine and Cabergoline are _______ inhibitors

prolactin

  • Prolactin is luteotropic in bitch and queen during the 2nd trimester. CL’s lyse in response to lowered prolactin levels
    • Cabergoline is a serotonin antagonist
    • Bromocryptine is a dopamine agonist

14

Before mid-gestation, what drug(s) is/are most commonly used to induce abortion in the bitch?

Lutalyse®

15

After mid-gestation, what drug(s) is/are most commonly used to induce abortion in the bitch?

Bromocriptine + Lutalyse®

  • Bromocryptine 10 mcg/kg PO TID plus Lutalyse ® 0.1mg/kg SQ TID (less side effects with low dose)
  • Side effects lessen with subsequent doses
  • Takes 10-12 doses before abortion is complete
  • Recheck with U/S to ensure abortion complete

 

16

What drug is used to induce estrus when a bitch does not come back into estrus for a prolonged period?

Cabergoline (Dostinex®)

  • Prolactin inhibition may shorten anestrus
  • 70% will induce within 14 days
  • Make sure low P4 before start and had normal (5 mo) interestrous interval
  • Can take 7 to 50 days though – be prepared for expense if longer time interval
  • Look for bleeding and vulvar edema to start cytologies/Progesterone measurements or check cytology and vag speculum q7d until in proestrus
  • May get coat color changes esp with tx beyond 3 weeks but will go away when next sheds

17

What is the drug of choice for treatment of unwanted uterine contractions in the bitch?

Terbutaline (β2 agonist)

  • Progesterone will also decrease uterine contractions if Terbutaline not totally effective
  • Avoid high Terbutaline dosages as may cause cardiac effects
  • Look for dead pup, infection or inflammation as cause of abnormal contractions

18

This drug is used for a bitch that whelps with little to no milk:

Domperidone

↓ dopamine & ↑ prolactin

↑ milk production

19

Which of the following drugs would be appropriate to give in a protocol to induce an abortion in a bitch at around 45 days of gestation?

  • Estrogen
  • Testosterone
  • Bromocriptine
  • Domperidone

Bromocriptine