Catecholamines iBook Flashcards Preview

Neuroscience 1 > Catecholamines iBook > Flashcards

Flashcards in Catecholamines iBook Deck (25):
1

what is the RL enzyme in formation of dopamine, norep, and ep

tyrosine hydroxylase

2

what enzyme is used to convert norep to epin

PNMT

3

4 major pathways in the brain that utilize dopamine at their NT

1) substantia nigra dopaminergic pathway: motor control, damaged in parkinson's disease

2) mesolimbic dopaminergic pathway: from ventral tegmental area to nucleus accumbens, pleasure/reward and alteriation assocaited with addiction

3) mesocortical: ventral tegmental area to cortex, attention and higher levels of consciousness
-damage alters cognition/consciousness, dysfunction linked to schizophrenia

4) tuberinfundibular pathway: hypothalamus to anterior pituitary, blocks prolactin release from anterior pituit

4

what cluster of neurons is norepinephrine found in
and role of norep

loucs ceruleus,
-crutial role in waking us up and awareness

5

which VMAT is involved in the neuronal vesicular monamine transport

VMAT2

6

VMAT 1 and 2 are sensitive to what drug

reserpine, reduces the amount of monoamines packaged into the vesicles
-used to treat hypertension

7

alpha 1 subtype catecholamine receptors

Gq

8

alpha 2 subtype catecholamine receptor

Gi

9

B adrenergic receptors are what type of G

Gs

10

dopamine receptors, D-1 like receptors

D1 and D5
-activate Gs

11

D2 like receptors

D2,3,4
-activate Gi

12

which dopamine receptors are found in high concentration in regions of the brain innervated by substantia nigra

D1: movement
D2: inhibition of motion

13

which dopamine receptor is strongly associated with pleasure/reward system

D3

14

what 2 enzymes are used to destroy catecholamines

MAO and COMT

15

what 2 enzymes are required for serotonin syn

trp hydroxylase (RL step)
-5-hydroxytrp decarboxylase

16

5-HT2a receptor associated with

platelet aggregation and SM contraction

17

which of the 5-HT receptors is the only one that is ionotropic

5-HT3

18

5-HT1 receptors are assocaited with __ proteins

Gi

19

5-HT2 receptors are assocaited with ___ proteins

Gq

20

5-HT2c receptor role

controlling normal body weight and preventing seizures

21

what enzyme removes serotonin from synaptic cleft

MAO

22

Histamine receptors how many

3
-H1,2,3

23

H3 receptors

located presynaptically and activation of these receptors decreases the release of histamine from presynaptic terminal

24

H1 and H2 receptors

mediate neruonal effects of histamine

25

removal of histamine from synaptic cleft

diamine oxidase