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Flashcards in NT systems iBook Deck (15)
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1
Q

location of Ach as NT in peripherhy

A
NMJ
autonomic preganglionic synapse
parasympathetic post gang fibers
sympathetic post gang fibers that innervate sweat glands/muscle vasodilators
amacrine cells in retina
2
Q

location of Ach in CNS

A

striatum (motor control)

brainstem arousal system

3
Q

enzyme to make Ach

A

choline acetyltransferase

4
Q

catabolism of Ach

A

acetylcholinesterase

1) true or specific choinesteraste on post synaptic cell membrane
2) pseudocholinesterase found in blood and acts on other choline esters

  • hydrolyses Ach to acetate and choline
    • choline recycled by presynaptic cell uptake, acetate diffuses away
5
Q

what are Ach muscarinic receptors blocked by

A

atropine

6
Q

ach nicotinc receptors

-fetal vs adult subunits

A

fetal: 2 a, b, y, sigma
adult: 2 a, b, y, e

-change in subunit structure decreases open time of channel but increases sodium entry (larger conductance)

7
Q

pancreatic beta cells produce and release ___

A

GABA

8
Q

antibodies to GAD (glutamate decarboxylase) are most common identified in what disease

A

Type 1 (juvenile) diabetes

9
Q

GABA(B)

A

coupled to a heterodimer! G protein (Gi and Gq)

10
Q

GABA(C) receptor

A

found in retina

ionotropic, chloride conductance

11
Q

general anesthetics work primarily at what receptors

A

extrasynaptic GABA receptors

12
Q

proenkephalins 2 extra subtypes

A

octapeptide

heptapeptide

13
Q

spinal cord CB-1 receptors

A

associated with modification of nociceptive inputs

14
Q

neocortical CB-1 receptors

A

associated with neuroprotection against excitotoxicity

15
Q

hippocampal and basal ganglia CB-1 receptors

A

associated with changes in affect