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Flashcards in NT systems iBook Deck (15):
1

location of Ach as NT in peripherhy

NMJ
autonomic preganglionic synapse
parasympathetic post gang fibers
sympathetic post gang fibers that innervate sweat glands/muscle vasodilators
amacrine cells in retina

2

location of Ach in CNS

striatum (motor control)
brainstem arousal system

3

enzyme to make Ach

choline acetyltransferase

4

catabolism of Ach

acetylcholinesterase

1) true or specific choinesteraste on post synaptic cell membrane

2) pseudocholinesterase found in blood and acts on other choline esters

-hydrolyses Ach to acetate and choline
-choline recycled by presynaptic cell uptake, acetate diffuses away

5

what are Ach muscarinic receptors blocked by

atropine

6

ach nicotinc receptors
-fetal vs adult subunits

fetal: 2 a, b, y, sigma
adult: 2 a, b, y, e

-change in subunit structure decreases open time of channel but increases sodium entry (larger conductance)

7

pancreatic beta cells produce and release ___

GABA

8

antibodies to GAD (glutamate decarboxylase) are most common identified in what disease

Type 1 (juvenile) diabetes

9

GABA(B)

coupled to a heterodimer! G protein (Gi and Gq)

10

GABA(C) receptor

found in retina
ionotropic, chloride conductance

11

general anesthetics work primarily at what receptors

extrasynaptic GABA receptors

12

proenkephalins 2 extra subtypes

octapeptide
heptapeptide

13

spinal cord CB-1 receptors

associated with modification of nociceptive inputs

14

neocortical CB-1 receptors

associated with neuroprotection against excitotoxicity

15

hippocampal and basal ganglia CB-1 receptors

associated with changes in affect