CDs & ILs Flashcards
The T helper lymphocyte has which CDs?
CD4
CD3
CD28 (binds with CD80/86 APC)
The CTL has which CDs?
CD8 (requires IL-2 from Th cell for activation)
LFA-1
NK Cells have which CDs?
CD16 and CD56 but NOT CD3
B-cells have which CDs?
CD80/86 (as APC)
CD40 (most potent activation signal which binds with CD40 T-cell receptor)
CD19/20/21 (for identification)
T-cells have which CDs?
CD3 (identifies mature T-cell
CD28 (receives activation co-signal from CD80/86 APC)
CD40-receptor
LFA-1 (Leukocyte Function-associated Antigen-1) – an adhesion molecule on T-cells
What surface molecules do APCs have?
MHC-II
CD80/86
ICAM-1 (binds to LFA-1 on T-cells)
LFA-3 (binding molecule for CD2)
Interleukin-1, IL-1 source and activity
Macrophages, APCs
Co-stimulates TH cell activation, Promotes T-cell proliferation (stimulates IL-2 receptors); inflammation
Interleukin-2, IL-2 source and activity
CD4-cells
T- & B-cell growth factor; activates & enhances T, B, and NK cells
Interleukin-3, IL-3 source and activity
Activated CD4-cells
Promotes proliferation of a variety of cells (colony stimulating factor)
Interleukin-4, IL-4 source and activity
Activated CD4-cells
Co-stimulates B-cells; Promotes B-cell growth & differentiation; Promotes IgE reactions
Interleukin-5, IL-5 source and activity
Activated CD4-cells
Stimulates differentiation of B-cells & Eosinophils; Promotes IgA &
Interleukin-6, IL-6 source and activity
Macrophage, T-cells
Mediates acute-phase response; enhances B-cell growth; Induces B-cell differentiation to plasma cell
Interleukin-8, IL-8 source and activity
Macrophages
Chemoattracts neutrophils; promotes neutrophil adherence to vascular endothelial cells
Interleukin-10, IL-10 source and activity
CD4-cells
Inhibits cytokine synthesis; down-regulates cellular response; enhances immunoglobulin secretion
Interleukin-12, IL-12 source and activity
Macrophages
Activates NK, CD4 TH1 cells
