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Immunology and Serology MDLS 4169 > Cells and Tissues of Immune System > Flashcards

Cells and Tissues of Immune System Flashcards

1
Q

What are the types of WBC?

A

-neutrophils
-eosinophils
-basophils
-monocytes
-lymphocytes
- NK cells

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2
Q

50-60% of circulating WBC, also found in tissues
First responders to infection
Phagocytosis

A

Neutrophils

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3
Q

Also known as PMN

A

Neutrophils

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4
Q

What is the size of neutrophils?

A

10-15 micrometers

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5
Q

Neutrophils have a large number of ___________ Staining granules in cytoplasm

A

Neutral

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6
Q

How many lobes are Usually seen in the nucleus of neutrophils?

A

2-5

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7
Q

WBC that kills parasites and participate in allergic reactions

A

Eosinophils 

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8
Q

_______% of circulating WBC in non-allergic person and found at site of response against allergen or parasite

A

1-3

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9
Q

What is the size of eosinophils? 

A

12-14 micrometers

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10
Q

What color are eosinophils large granules? What stain causes this color?

A

Orange/red granules

Eosin dye

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11
Q

Eosinophil granules contain __________ proteins that can damage membrane of parasite.

A

Cationic 

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12
Q

What is the shape of eosinophils nucleus? 

A

Bilobed

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13
Q

This WBC Participates in allergic or parasitic responses but makes up less than 1% of WBC in blood

A

Basophil

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14
Q

What is the size of basophils?

A

10-15 micrometers

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15
Q

What color granules do basophils have?
What do the granules contain?

A

Bluish – purple

histamine, cytokines, etc.

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16
Q

What is the typical lifespan of basophils?

A

Very short, only a few hours

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17
Q

This WBC is phagocytic and migrates into tissues to become macrophages

A

Monocyte

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18
Q

What is the Percentage of circulating monocytes?

A

4-10%

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19
Q

What is the size of Monocytes?

A

12-22 micrometers

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20
Q

What is the shape of monocyte nucleus?

A

Large irregularly folded or horseshoe shaped nucleus

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21
Q

How do you monocytes typically stain?

A

Cytoplasm stains gray-blue, containing small granules (granules contain substances to kill organisms, etc.) 

22
Q

These arise from monocytes that migrate into tissues

A

Macrophages (Tissue cells)

23
Q

True or false

Macrophages play a role in innate immunity, and initiating and regulating adaptive immune responses

A

True

24
Q

What are some things that macrophages can do?

A

• microbial killing
• Antitumor activity
• Intracellular parasite eradication
• Phagocytosis
• Secretion of cell mediators (e.g. Cytokines- hormones of the immune system)

25
Q

- cells found in tissues, particularly skin, connective tissues and mucosal tissues
-Resemble basophils but come from a different lineage

A

Mast cells

26
Q

The granules of this cell type contain histamine
Play a role in defense against parasites, as well as allergic reactions

A

Mast cell

27
Q

-covered with long Membranousextensions that make them resemble nerve cell dendrites 

A

Dendritic cells 

28
Q

These are considered the most effective APC in the body and the most potent phagocytic cell

A

Dendritic cells 

29
Q

Lymphocytes represent between ______ and ______ % Of the circulating wbc’s

A

20, 40

30
Q

-Mononuclear cells
-no granules in most

A

Lymphocytes

31
Q

What are the types of lymphocytes?

A

• B cells (Antibody production)
• T cells (Regulation of immunity, killing of virus infected and cancer cells Specificity
• natural killer cells (killing a virus infected in cancer cells innate immunity, no specificity

32
Q

Antibodies help ___________ Cell populations

A

Identify

(examples: CD3, CD4, CD8)

33
Q

CD8 is found on what type of cells?

A

Cytotoxic T cells

34
Q

CD3 is found on what type of cells?

A

T cells, Associated with T cell antigen receptor

35
Q

CD4 is Associated with what type of cells?

A

T-helper cells (CD3+ and CD4+)

36
Q

Function as potential sites for contact with foreign antigens
Provides the microenvironment to generate immune responses 

A

Secondary lymphoid organs

37
Q

Examples of secondary lymphoid tissue?

A

Spleen, lymph nodes, MALT, CALT

38
Q

What part of the spleen destroys old RBCs and makes up for more than 1/2 of the total volume

A

Red pulp

39
Q

Comprises about 20% of the total weight of a spleen
Contains lymphoid tissue arranged around arterials in a Periarterial lymphoid sheath containing T cells

A

White pulp of spleen

40
Q

Area of the spleen that contains B cells not yet stimulated by antigen

A

Primary follicles

41
Q

-Found on mucosal surfaces of the gastrointestinal, respiratory, and urogenital tracks
-A main portal of entry for foreign antigens
-Numerous macrophages and lymphocytes present

A

MALT

42
Q

T cells, monocytes, macrophages, and dendritic cells found on the skin

A

CALT

43
Q

What are the five principal types of leukocytes?

A

Neutrophils, eosinophils, basophils, monocytes, and lymphocytes

44
Q

What are the tissue cells involved in immunity?

A

• mast cells
• Dendritic cells
• Macrophages

45
Q

What are the cells that are involved in the innate immune response and are actively phagocytic?

A

Neutrophils, monocytes, macrophages, and dendritic cells

46
Q

________________ are the key cells involved in the adaptive immune response. 

A

Lymphocytes

47
Q

_________ cells are a type of lymphocyte that develop in the bone marrow and are capable of secreting antibody when mature

A

B

48
Q

T cells acquire their specificity in the thymus and consist of what to sub types? 

A

CD4 and CD8+

49
Q

______ cells kill virally infected or cancerous target cells without previous exposure to them. (Innate immunity) 

A

NK

50
Q

What are the two primary lymphoid organs?

A

Bone marrow and thymus

Immunology and Serology MDLS 4169 (12 decks)

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