Lab Exam 2

Question 1

Diseases with homogenous pattern

Answer 1

-high titer-SLE
-Low iter other CTD (Connective tissue diseases)

Question 2

antigens associated with homogenous

Answer 2

• dsDNA
• ssDNA
• DNP
• histone

Question 3

Diseases with peripheral pattern

Answer 3

• High titer-SLE
• MCTD (Mixed Connective Tissue Disease)
• Scleroderma
• Sjogren’s Syndrome
• Low titer other CTD (Connective Tissue Disease)

Question 4

antigens associated with peripheral

Answer 4

• Sm (Smith Antigen) – highly specific for SLE
• RNP
• Scl-70
• SS-B

Question 5

diseases with speckled

Answer 5

• SLE
• Mixed Connective Tissue Disease (MCTD)
• Sjogren’s Syndrome (SS)
• Scleroderma

Question 6

antigens associated with speckled

Answer 6

• SS-B
• Scl-70RNP
• Sm (SLE)

Question 7

Diseases associated with nucleolar pattern

Answer 7

• High titer Scleroderma
• Sjogren’s Syndrome

Question 8

Antigens associated with nucleolar?

Answer 8

• 4-65 RNA

Question 9

diseases associated with Anti-centromere AB (ACA)

Answer 9

CREST

Question 10

antigens associated with Anti-centromere AB (ACA)

Answer 10

Centromere

Question 11

Cytoplasmic Staining:

Mitochondrial (AMA) is associated with what diseases?

Answer 11

• Biliary Cirrhosis
• Other liver diseases

Question 12

Cytoplasmic Staining:

Mitochondrial (AMA) pattern is associated with what antigen?

Answer 12

mitochondira

Question 13

Cytoplasmic Staining:

smooth muscle pattern is associated with what diseases?

Answer 13

• Mononucleosis
• Chronic hepatitis
• Other Liver Diseases

Question 14

Cytoplasmic Staining:

smooth muscle pattern is associated with what antigen?

Answer 14

actin