Test 3: Quiz 5 Questions Flashcards
A 6-month-old baby has suffered from recurrent bacterial infections. Flow cytometry results indicate a lack of B cells but the presence of normally functioning T cells. What is the most likely diagnosis?
Bruton’s tyrosine kinase deficiency
2.) A 7-month-old boy is seen by a specialist because of hypocalcemia, viral pneumonia, a history significant for recurrent diarrhea, and oral candidiasis. An x-ray reveals the lack of a thymic shadow. A likely diagnosis for this boy is:
DiGeorge anomaly
A 9-month-old boy is suspected of having an immune deficiency because he had many recurrent infections with Streptococcus pneumonia. Laboratory tests reveal a normal percentage of T cells and T-cell subsets but a lack of mature B cells and immunoglobulins. This boy most likely has:
X-linked agammaglobulinemia
A child suspected of having an inherited humoral immunodeficiency disease is given a diphtheria/tetanus vaccine. Two weeks after the immunization, his level of antibody to the specific antigens is measured. Which result is expected for this patient if he does have this deficiency?
No change in the level of specific antibody
A nitroblue tetrazolium test shows little color in cells observed under a microscope. What disease does this finding correlate with?
Chronic granulomatous disease
A patient has a monoclonal serum band. Which of the following additional criteria would support a diagnosis of multiple myeloma?
Increased abnormal plasma cells in bone marrow or monoclonality of plasma cells
A patient’s immunofixation electrophoresis shows excessive amounts of free monoclonal light chains. These light chains are referred to as:
Bence Jones proteins
A transplant patient on a follow-up visit to his physician is noted to have progressive fibrosis and scarring with narrowing of the vessels leading to the transplanted organ. What type of rejection is occurring?
Chronic
A transplantation patient suffers an organ rejection within hours after the procedure. What type of rejection occurred?
Hyperacute
Decreased CD3-positive lymphocytes and a lack of responsiveness to phytohemagglutinin in the circulation are typically associated with:
DiGeorge anomaly.
If a patient suffers with an increased susceptibility to septicemias by Neisseria sp., but not other bacteria. What complement activities is most likely deficient in this patient?
Formation of membrane attack complex
In a patient who is exhibiting signs of graft-versus-host disease, which cell type is most likely responsible for the reaction?
T cells
True or False:
In indirect allorecognition, the host’s T helper cells recognize foreign protein and uptake, process, and present it to recipient antigen-presenting cells (APCs).
False
True or False:
In direct allorecognition, the recipient T cells bind and respond directly to foreign HLA proteins.
True
Patients with recombinase activating gene 1 (RAG-1) or RAG-2 deficiencies have decreased numbers of:
lymphocytes
