CF And The GIT Flashcards
(9 cards)
1
Q
Name 3 causes of clubbing
A
- cancer
- lung fibrosis
- CF
2
Q
What systems do CFTR affect? Where CFTR present?
A
- intestines
- liver
- pancreas
- GU system
- lungs
- brain
3
Q
Distribution of CFTR in the ileum
A
CFTR gradually decreases from duodenum to ileum
High expression in the proximal colon and caecum
4
Q
Proportion of CFTR carriers
A
1/25
5
Q
Babies and CF
A
Muconium ileum - cannot have first poop due to water not being able to enter gut lumen
6
Q
What is given to defective pancreas in CFTR
A
Lipase amylase protein - CREON
As pancreas not producing
To digest fat to enable absorption of fat and Fat solvable vitamins
7
Q
What can decrease GI symptoms of CF
A
ETI therapy
Elexacaftor tezacaftor ivacaftor
8
Q
A
- liver disease
- alkaline si pH
- meconeum ileum/distal intestinal obstruction syndrome
- appendicitis
- altered gastric transit time
9
Q
GI Complications of CF
A
Panc malabsorption
Abdominal symptoms
Gut dysbiosis
Gut inflammation
Cancer risk
