Chap 5: Bone (Cells) (exam 2) Flashcards Preview

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Flashcards in Chap 5: Bone (Cells) (exam 2) Deck (34)
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1
Q

What are the cell types in bone?

A
  1. Osteoprogenitor
  2. Osteoblasts
  3. osteocytes
  4. bone lining cells
  5. osteoclasts
2
Q

what is the appearance of osteoprogenitor cells?

A

Flat

3
Q

where are osteoprogenitor cells located

A

endosteum and periosteum

4
Q

osteoprogenitor cells are derived from where?

A

usually- mesenchyme cells

possibly- chondrogenic cells

5
Q

what is the function of osteoprogenitor cells

A

usually to change into another bone cell type aka osteoblasts

6
Q

can osteoprogenitor cells can or can not under go mitosis

A

yes they can

7
Q

Osteoblasts appearance is what?

A

cuboid to columnar

8
Q

what is the location of osteoblasts

A

endosteum and periosteum

9
Q

osteoblasts are derived from what cell

A

osteoprogenitor cells

10
Q

What are the functions of osteoblasts

A

produce osteoid,
produce materials (matrix vesicles),
respond to PTH directly

11
Q

in response to PTH osteoblast will do what?

A

they will produce a factor OPG (that cause the creation of new osteoclasts),
secrete osteoclast stimulating factor (reabsorb bone),
cause them to produce enzymes to condition bone for osteoclasts

12
Q

can osteoblast undergo mitosis

A

no

13
Q

Osteocytes have what appearance

A

conforms to lacuna

14
Q

what is the location of an osteocyte?

A

surrounded by bony matrix

15
Q

What is the function of osteocytes?

A
  1. maintain the matrix and monitor the matrix
  2. release factors to influence osteoblast activity
  3. release factors to cause the creation of new osteoclasts
16
Q

can osteocytes undergo mitosis

A

no

17
Q

Bone lining cells appear to be what shape?

A

flat

18
Q

what is the location of Bone lining cells

A

in the endosteum

19
Q

bone lining cells are derived from what?

A

usually-osteoblast

possibly-osteocytes

20
Q

what is the function of bone lining cells

A

primarily to wait to become an osteoblast again

21
Q

do bone lining cells go through mitosis?

A

no way

22
Q

Osteoclast appear how?

A

large and multi-nucleated

23
Q

osteoblasts are located where

A

endosteum and periosteum

24
Q

osteoclasts are derived from what

A

Peri-osteoclasts (related to monocytes)

25
Q

what is the function to osteoclasts

A

to reabsorb bone

26
Q

bone reabsorption occurs where

A

in the subosteoclastic compartment

27
Q

What are the steps at reabsorbing bone?

A

inorganic matrix dissolves first then the organic matrix goes next

28
Q

Inorganics dissolve using what

A

strong acids (primarily carbonic acid)

29
Q

The organic will break down fast due to what?

A

the low pH from the inorganics dissolving first

30
Q

The organics are broken down by what

A

lysosomal enzymes

31
Q

at the end of the organics breaking down what will be about original to not damage surrounding cells

A

the pH will be about normal

32
Q

What are the two hormones that regular osteoclasts

A

PTH and Calcitonin

33
Q

PTH will do what to osteoclasts

A

it will increase osteoclast activity view causing osteoblasts to secrete osteoclast-stimulating factor

34
Q

Calcitonin does what to osteoclasts

A

will decrease osteoclast activity (off switch)