Chapter 10 part 1 Flashcards by Victoria Marie

Plasma

Liquid ecm and protein rich

How well did you know this?

Not at all

Perfectly

Erythrocyte

RBC

How well did you know this?

Not at all

Perfectly

Leukocyte

WBC

How well did you know this?

Not at all

Perfectly

Platelets

Thrombocytes, 90% water

How well did you know this?

Not at all

Perfectly

Hematocrit

Packed erythrocytes, like lab work

How well did you know this?

Not at all

Perfectly

Plasma make up

90 percent water, 10 percent i

How well did you know this?

Not at all

Perfectly

proteins in plasma

albumin, globulins and fibrogen
-all but the large protein can diffuse through wall into intracellular space

How well did you know this?

Not at all

Perfectly

albumin

-main plasma protein
-smallest protein
-made in liver
-colloid osmotic pressure
-

How well did you know this?

Not at all

Perfectly

globulins

-immunglobulin and nonimuno globulin

How well did you know this?

Not at all

Perfectly

immuno

-immune system moelcule that is made by the plasma cell

How well did you know this?

Not at all

Perfectly

nonimmuno

-made by the liver
-maintains osmotic pressure
-IS THE CARRIER PROTEIN FOR IRON AND HEMOGLOBIN

How well did you know this?

Not at all

Perfectly

fibrogen

largest protein
-turns into fibrin (insoluble protein)
-cant diffuse

How well did you know this?

Not at all

Perfectly

bloodclot

network of erythrocytes in a network of fibrin

How well did you know this?

Not at all

Perfectly

anticoagulant

-citrate or heparin
-prevents clots in sample

How well did you know this?

Not at all

Perfectly

citrate

binds to calcium

How well did you know this?

Not at all

Perfectly

heparin

blocks clotting factors

How well did you know this?

Not at all

Perfectly

serum

plasma with no coagulant factors

How well did you know this?

Not at all

Perfectly

what surrounds tissue cells?

interstitial fluid
-it has the same electrolyte composition as plasma

How well did you know this?

Not at all

Perfectly

what is an example of a microenvironement?

the blood brain barrier

How well did you know this?

Not at all

Perfectly

blood smear

-not put in paraffin
-monolayer of cells
-air dry
-stained

How well did you know this?

Not at all

Perfectly

what is the stain name for blood smear?

romanovsky stain
-eosin + blue

granulocytes

-neutrophils
-eosinophils
-basophils

agranulocytes

-lymphocytes
-monocytes

what do basic dyes stain?

-nuclei, granules of basophiles and rna of cytoplasm

what do acidic dyes stain?

rythrocutes and granules of eosinophils

what is basic dye?

-azures -metachromatic (will look violet/ red)

erythrocyte characteristics

-no nucleus -bind oxygen to deliver it and co2 to remove -7.8 nm diameter -.8nm central thickness -last 120 days -uniform eosin stain -lipid bilayer w 2 proteins -have hemoglobin

what removed rbc?

-macrophased in spleen, bone marrow and liver

2 proteins of erythrocytes

-integral and peripheral proteins

integral proteins

-membrane proteins -band 3 protein -blood group antigen -glycophorin (attach protein network tot he membrane)

what does band 3 protein do?

binds hemoglobin and anchors cytoskeleton proteins

peripheral proteins

-inside the cell membrane -lattice network that is parallel to membrane and anchored by globular proteins

hemoglobin

protein that binds 02 and co2 -cause uniform eosin stain hba = adults

leukocytes

-2 types (either have or dont have specific granules) -all have azurophilic granules

have specific granulocytes

granulocytes

dont have granulocytes

agranulocytes

azurophilic granules

lysosomes -digest material with hydrolases

neutrophils

-wbc -the most of these wbc in the blood -multilobbed nucleus -ploymorph -2-4 lobes joined by nuclear strands -not static -has specific, azurphilic and tertiery granules -mobile cells -and the first cells to enter damage

what does the x chromosome do?

create a barr body on one lobe

specific granules

-secondary -smallest -have enzymes -most common

tertiery

-have phosphates -metalloproteinase (collagenases)

what helps the neutrophil migrate through connective tissue?

metalloproteinase

what controls the migration of neutrophils?

adhesion molecules on the surface that interact w ligands on epithelial cells

phases of adhesion molecules

-selectins (first) -integrins (second) -immunoglobulin (third) -once they attach the neutrophil extends a pseudopod to an intercellular junction -respiratory burst (used for intracellular killing)

what causes neutrophil granulocyte appearance?

actin filaments

what directs the neutrophil to site of damage?

chemotaxis

how do neutrophils kill?

phagosome (eat bacteria)

lyeloperoxidase

lysosomal enzyme

nitrogen intermediaries

do NOT kill bateria in humans -only oxy do

how are bacteria killed w oxygen?

-the oxy breaks down the membrane -lysosomal hydrolytic enzyme eats it -THIS IS LESS EFFICIENT THAN THE OXYGEN PATHWAY

MONOCYTE

-SECONDARY RESPONSE TO INJURY -become macrophages -phacotye debris

what happens at the same time as monocyte response to injusry?

fibroblasts release ground substance