Chapter 15 Flashcards

1
Q

The ability to cause disease is known as ______

A

Pathogenicity

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2
Q

The degree of pathogenicity is known as ________

A

virulence

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3
Q

______ adhere to host tissues

A

microbes

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4
Q

_______ damage host tissues

A

microbes

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5
Q

_____ are toxins or microbial waste products

A

microbes

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6
Q

What are the four portals of entry?

A
  1. Mucous membranes
  2. Skin
  3. Parenteral route
  4. Preferred portal of entry
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7
Q

How many portals of entry are portals via mucous membranes?

A

Four

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8
Q

What are the four sub-portals via mucous membrane?

A
  1. Respiratory tract
  2. Gastrointestinal tract
  3. genitourinary tract
  4. Conjuctiva
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9
Q

Conjuctiva is a mucous membrane portal of entry. What falls under conjuctiva? What are three infections of conjuctiva?

A

Eyelids and covers the whites of eyelids.

  1. conjunctivitis
  2. Trachoma
  3. Opthalmia neonatorum
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10
Q

The genitourinary tract is a mucous membrane portal of entry. What does that entail?

A

It’s sexually contracted. Causes HIV, genital warts, chlamydia, and syphillis

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11
Q

The gastrointestinal tract is a mucous membrane portal of entry. What does that entail?

A

Food, water, contaminated fingers. Causes giardia, shigellosis, and cholera

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12
Q

The respiratory tract is a mucous membrane portal of entry. What does that entail?

A

The nose and mouth. Causes the common cold, influenza, and pneumonia

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13
Q

The skin is a portal of entry. Microbes gain access through….

A

hair follicles and sweat gland ducts.

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14
Q

What is interesting about skin?

A

Largest organ in the body

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15
Q

What is parenteral?

A

administered or occurring elsewhere in the body than the mouth and alimentary canal.

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16
Q

Parenteral is a port of entry. How do microbes enter the tissue?

A

Microbes are deposited directly into tissues when barriers are penetrated

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17
Q

Parenteral ports of entry include….

A

Punctures, injections, bites, cuts, surgery, and dry skin

18
Q

What diseases can someone contract via parenteral ports?

A

HIV, hepatitis viruses, tetanus and gangrene

19
Q

What is the preferred route?

A

Microbes causing infections through their specific portal of entry

20
Q

What is the preferred route for Salmonella typhi?

A

Signs and symptoms identified when swallowed. Gastrointestinal tract. No reaction on skin

21
Q

What is the preferred route of Streptococcus pneumonia?

A

Inhaled…respiratory tract. No signs noticed if swallowed.

22
Q

What is the preferred route for Bacillus anthracis?

A

More than one entry.

23
Q

IDv50

A

Infectious dose for 50% of a sample population. Measures virulence of a microbe

24
Q

LDv50

A

lethal dose for 50% of a sample population. Measures potency of a toxin.

25
How many endospores enter tissue via skin? (Bacillus anthracis)
10-50
26
How many endospores enter body through inhalation? (Bacillus anthracis)
10,000-20,000
27
How many endospores enter the body through ingestion? (Bacillus anthracis)
250,000-1,000,000
28
What is the name used when measuring the virulence of a microbe?
IDv50
29
What is the name used when measuring the potency of a toxin?
LD50
30
LD50 is _____ and ID50 is ____
lethal; infectious
31
What is the lethal dose of Botulinum?
0.03 ng/kg
32
What is the lethal dose of Shiga toxin?
250 ng/kg
33
What is the lethal dose for Staphylococcal enterotoxin?
1350 ng/kg
34
adherence vs adhesins
Adherence is pathogens attaching to the host tissues whereas adhesins is after they've attached and the pathogens bind to receptors on the host cells (ligands)
35
______: pathogens attach to host tissues
adherence
36
_____ on the pathogen bind to receptors on the host cells
adhesins (ligands)
37
______ and ______ are two types of adhesins
Glycocalyx and Fimbriae
38
Microbes form _____ (share nutrients)
Biofilms
39
What are glycocalyx and fimbriae?
adhesins that pathogens use to bind to the host cells
40
What are the three ways bacteria penetrate host defenses?
1. Capsule 2. Enzymes 3. Cell wall components