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Pre-pharmacology > Chapter 15 (pulmonary drugs) > Flashcards

Chapter 15 (pulmonary drugs) Flashcards

(61 cards)

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1
Q

COPD

A

chronic obstructive pulmonary disease; pts. have obstructed breathing with big chests, patients cannot exhale well b/c of air trapping

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2
Q

lower respiratory infections

A

called laryngotracheitis; infections of trachea, bronchi, and bronchioles
*though laryngotracheitis is usually just called an URI or bronchitis

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3
Q

bronchodilators

A

relax bronchial smooth muscle to treat asthma, emphysema (COPD), and exercise induced asthma (EIA)
Can be given by mouth, injection, nebulized liquid, or powder

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4
Q

EIA

A

exercise induced asthma

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5
Q

Primatene Mist

A

OTC inhaler of epinepherine; non-selective adrenergic agonist; best drug for bronchospasm, especially in emergency situations; although effects on heart and BP limit its use

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6
Q

front door bronchodilators

A

sympathomimetic drugs; B2 agonists that dilate bronchial smooth muscle

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7
Q

non-selective sympathomimetic bronchodilators

A

epinepherine, ephedrine, amphetamine, cocaine, etc.

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8
Q

Proventil MDI

A

albuterol; prototypical B2 selective agonist; rescue inhaler

Fast onset and short acting (lasts 4-6 hours)

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9
Q

Ventolin

A

albuterol; prototypical B2 selective agonist; rescue inhaler

Fast onset and short acting (lasts 4-6 hours)

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10
Q

LABA

A

long-acting B2 agonists used for prophylactic treatment b/c of 0.5 hour onset time (salmeterol and formoterol); last up to 12 hours

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11
Q

Servent

A

salmeterol; LABA; used for prophylaxis b/c of 0.5 hour onset time and 12 hour lasting effect

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12
Q

formoterol

A

LABA; used for prophylaxis b/c of 0.5 hour onset time and 12 hour lasting effect

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13
Q

Advair

A

salmeterol and flucticasone

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14
Q

back door bronchodilators

A

parasympatholytics; reduce parasympathetic effect of bronchoconstriction in order to dilate the airway

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15
Q

ipratropium

A

prototype parasympatholytic back door bronchodilator; has less cardiac effect than atropine and is longer acting

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16
Q

“vent”

A

means its a metered dose inhaler

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17
Q

MDI

A

metered dose inhaler; can be difficult to use b/c shouldn’t put mouth on it or not enough air will enter and drug will not move into lungs
Spacers help to solve this problem by allowing more volume in with the breathe so mouth can go directly on it

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18
Q

side door bronchodilators

A 
xanthine derivatives; have nothing to do with ANS antagonism
Phosphodiesterase inhibitors (specific type) that work at cellular level to increase cAMP levels to yield brochodilation and increase breathing rate by stimulating respiratory centers
*also stimulate brain, so cause seizures in high doses and restlessness; stopped being used when corticosteroids and LABAs got better
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19
Q

cocoa beans

A

naturally rich in methylxanthine drugs caffeine and chemical relatives theobromine and theophylline

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20
Q

theobromine

A

xanthine; found in hot chocolate

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21
Q

Theo-Dur

A

theophylline; methylxanthine commonly found in black tea

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22
Q

nebulizers

A

turn liquid medicine into mist that can be breathed in easy to get medicine into lungs

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23
Q

Advair

A

salmeterol (LABA) and fluticasone (corticosteroid) combination
Often used as powder

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24
Q

powder vs. propellant

A

powder is easier to inhale and does not require the coordination of breathing required to take the propellant powered MDIs

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25
LTAs
leukotriene rc antagonists (inhibit action of LT eicosanoids which are known to cause bronchoconstriction); treat asthma and severe hay fever that does not respond to antihistamine therapy *hard to get insurance to pay for this as allergy treatment and must get waiver and show that you get much better relief than from antihistamines
26
Singulair
montelukast; leukotriene rc antagonist, oral tablet usually 1/day
27
Accolate
zafirlukast; leukotriene rc antagonist
28
Ultair
pranlukast; leukotriene rc antagonist in late stage trials for use in USA
29
cromolyn sodium
mast cell stabilizer; formulated as a liquid for nubulizers for inhalation (helps treat allergic rhinitis, allergic conjunctivitis, asthma, or general hay fever)
30
mast cell stabilizers
coat mast cells and prevent them from releasing their allergy causing granules; inert drugs Only useful prophylactically *also now used for people who get ulcers from allergies
31
Intal
cromolyn sodium inhalation aerosol; mast cell stabilizer
32
mast cell stabilizers and corticosteroids treatment timing
only used prophylactically b/c they do not promote immediate bronchodilation; just prevent bronchoconstriction from occuring
33
desensitizing immunotherapy
desensitization shots are a immunotherapy aimed at producing "blocking antibodies" of IgG type that prevent IgE-allergen complex from causing mast cell degranulation *but must be done 1/week with increasing doses of allergen for 2+ years and costs thousands
34
corticosteroids
reduces inflammation by suppressing inflammatory products products; not actual bronchodilators so don't help in acute phases of attack, but in 4-6 hours they dramatically reduce inflammation Great for maintenance asthma therapy to decrease the number of acute attacks and has less side e's than systemic corticosteroids
35
Vanceril MDI
beclomethasone; inhaled corticosteroid
36
Azmacort MDI
triamcinolone; inhaled corticosteroid
37
antibiotics for lung infections
same as those for ENT infections
38
oral antibiotics for treating bronchitis and pneumonia
pen VK, amoxicillin, macrolides like clarithromycin (Biaxin) and azithromycin (Zithromax), and ciproflaxacin (fluoroquinolone)
39
antitussive agents
suppress cough; opioids like dextromethorphan are the best
40
expectorant agents
thin mucous to aid in expectoration; guaifenesin derived from guaiac tree is most popular *although in some diseases, like pneumonia, coughing is actually essential and cough should not be suppressed
41
DXM
dextromethorphan; non-opioid antitussive that is relatively non-addicting
42
Robitussin
guaifenesin; mucolytic; expectorant
43
drugs to help smoking cessation
NicoDerm (nicotine patch), Nicorette (nicotine chewing gum), or other nicotine products like spray
44
Zyban
bupropion; antidepressant Rx drug used to help people quit smoking
45
Chantix
varenicline; first of new compounds called nicotine rc blockers that block nicotine rc's in brain Newest and most effective addition to antismoking therapy; allows patients to ween themselves off nicotine effects while still smoking
46
problem with new smoking therapies
serious neruopsychiatric symptoms including suicidal ideation and erratic behavior has led a decline in Rx'ing of Chantix
47
ephedrine
sympathomimetic front door brochodilator; found usually in injection or syrup
48
Isuprel
isoproterenol; sympathomimetic; front door bronchodilator
49
Benadryl
diphenhydramine; 1st gen antihistamine
50
doxylamine
1st gen antihistamine
51
Phenergan
promethazine; 1st gen antihistamine; also used as a antinausea drug but not very good
52
Claritin
loratadine; 2nd gen antihistamine
53
Allegra
fexofenadine; 2nd gen antihistamine
54
Zyrtec
cetirizine; 2nd gen antihistamine
55
Flovent MDI
fluticasone; inhaled corticosteroid
56
lung antifungal therapy
would need to be systemic; Difulcan (fluconazole) and Lamisil (terbinafine)
57
antiinfluenza drugs
Tamiflu and Relenza; or prevent it with IIV4 or LAIV
58
Wellbutrin
bupropion; antidepressant Rx drug used to help people quit smoking
59
Survanta
a surfactant extracted from ground up cow lungs used to treat lung disease of premature infants (which is also called hyaline membrane disease)
60
TB cause
Mycobacterium tuberculosis; a very large, acid-fast bacterium
61
the Venturi effect
is what allows the MDI to work better if held a couple inches away from the mouth when sucked in b/c of decrease in pressure of gas when moving through a narrow space

Pre-pharmacology (27 decks)

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