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Flashcards in Chapter 6 - Drugs mentioned during lecture Deck (10):

Drug used to increase contractility of the urinary bladder

Bethanechol (Urecholine - human label)
- Cholinergic stimulation to allow sphincter to relax and detrusor to contract
- Observe patient for signs of cholinergic toxicity
- ATROPINE is antidote


#1 Drug used to treat urinary incontinence/dribbling in older, spayed female dogs

Phenylpropanolamine (PPA, Proin 25)
- Side effect is anorexia
- This drug can be bought or compounded


Name of hormone replacement therapy, if Phenylpropanolamine doesn't work

Diethylstilbesterol (DES)


Agents to lower urine pH (more acid)

*NH4Cl (Ammonium Chloride) - cheap, safe
*dl Methionine
*Vitamin C (diff. forms, water-soluble)
All of these may be incorporated into acidifying diets for wellness feeding to dogs and cats! They also come in enteric-coated tablets and/or chewables.


Agent to raise urine pH (more alkaline)

*Potassium Citrate


Name the four diuretic classes (in order of importance)

1. Loop - Furosemide (Lasix)
2. Thiazides - old, traditional, safe, they "paralyze" sodium
3. Osmotic - 20% Mannitol solution will draw water out of tissues
4. Natural - this is not really used


1. What happens to urine when there's lots of ADH around?
2. What happens to urine when there's little ADH around?
3. Where is ADH produced?

1. Urine is very concentrated
2. High volume of urine being highly dilute
3. ADH is produced in the posterior pituitary (natural hormone)


Characteristics of Mannitol 20%

- Osmotic diuretic
- Na and water excretion
- Used to treat acute glaucoma and anuria


Important contraindications and cautions for Furosemide (Lasix)

- Anuria
- Depleted electrolytes
- Severe dehydration


Potassium sparing diuretic

Spironolactone (Aldactone - human label)
- Increases excretion of sodium with reabsorption of potassium to decrease risk of potassium depletion over time
- Usually not substituted for Lasix but can be
- Potassium supplements or potassium rich food could be given instead