Chapter 6-Immuno and Hypersensitivity Flashcards Preview

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Flashcards in Chapter 6-Immuno and Hypersensitivity Deck (130)
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1

What are Langerhans cells

Immature dendritic cells in the epidermis

2

What is the high affinity receptor on Mast cells and basophils

FcER1

3

How many days after antigen exposure does inflammation occur in type 3 hypersensitivity

10

4

What are the characteristics of the Ig alpha (CD79 alpha and beta) and beta in the BCR complex

Invariant proteins responsible for the signal transduction into the cell

5

What are drugs that can activate mast cells

Codeine, morphine, adenosine, melittin (in bee venom)

6

What are the characteristics of the autoimmune diseases

Chronic, with relapses and remissions, and damage is progressive

7

Innate immune receptors target what general characteristics of PAMPS on microbes

Microbial components that are essential for infectivity and thus can not be mutated to evade recognition

8

What disease is associated with HLA-B27

Ankylosis spondylitis

9

Many autoimmune diseases are associated with which HLA alleles

Class 2

10

What percentage of cells do natural killer (NK) cells make up in peripheral lymphocytes

5 to 10%

11

What percentage of reactions are nonatopic allergies

20-30% of immediate hypersensitivity

12

What are plasmablasts

Antibody secreting cells in the peripheral blood

13

How does the crosslinking in mast cells lead to compound production

1) Cross linking activated phospholipase A2
2) PL A2 take phospholipids into arachidonic acid
3) Activation of prostaglandin and leukotriene pathways

14

What is the gene that is most commonly associated with autoimmune diseases

PTPN22 (because the association with RA)

15

What are the primary costimulatory molecules for T cells

Binding of CD28 on T cells with B7/ CD80/86 on APCS

16

What cytokines activate NK cells and what are their function

IL2, 15 (Stimulate proliferation-NK from T line)
IL-12 (killing and IFN-gamma secretion)

17

What genes are located in 5q31

IL 4, 5, 9, 13, GM-CSF all which have a higher relation to asthma

18

What is the purpose of proteoglycans (chondroitin sulfate) in mast cells

Helps to package and store the amines

19

Which portion of MHC 2 does CD4 bind to

Beta 2

20

T helper cells use and stimulate other cells via which mechanism

Cytokines with CD40L binding to CD40 on APCs

21

What is occurring during the deposition of immune complexes

Antigen-antibody complexes are deposited into tissue. These complexes are of medium size, formed in slight antigen excess, and most pathogenic

22

What are the characteristics of the TCR

Noncovalent linked polypeptides (6 total)
CD3 and zeta chains are invariant (identical) in all cells

23

Where are C-type Lectin receptors (CTRs) located and what is their ligand

Expressed on the plasma membrane of macrophages and dendritic cells, where they detect fungal glycans

24

Inflamasome activation activates which caspase to form which product

Caspase 1 to produce IL-1

25

What receptors are not expressed on NK cells, and what kind of granules do they have

No TCRs or Igs, but contain azurophilic granules

26

What are the two receptors that help to limit autoreactive T cells

-CTLA4
-PD1

27

What are the characteristics of the late phase reaction of type 1 hypersensitivity

Infiltration of eosinophils, neutrophils, basophils, monocytes and CD4 T cells

28

In lymph nodes, where are the T cells located

Paracortex, next to the follicles

29

What are the likely sites of antigen-antibody complexes to be deposited

Where blood is filtered at high pressure into urine and synovial fluid, aka joints and glomeruli

30

What are the three phases in Type 3 hypersensitivity

1) Formation of immune complexes
2) Deposition of Immune complexes
3) Inflammation and tissue damage