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Flashcards in Chapter 1 Deck (119)
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1

What are the adhesion molecules in hemidesmosomes connecting to

Intermediate filaments

2

What is the result of the charge on the proteoglycan bristle

Recruits salt and water

3

What is the function of vascular endothelial growth factor B(VEGF-B) and PIGF

Embryonic vessel development

4

What is a condition that leads to reactive smooth ER hyperplasia

Repeated exposure to compounds that are metabolized by the SER, such as phenobarbital catabolism by cytP450

5

What is TGF beta inhibiting in the tissue

Collagen degredation by decreasing matrix metalloproteinase (MMP) and increasing tissue inhibators of proteinases

6

What is the big example of nonreceptor tyrosine kinase and what is it an analog of

SRC and Rous sarcoma virus

7

In which structure do proteolytic enzymes begin significant digestion

Late endoscope

8

What is the function one the RISC complex

Bind to mRNA and silence via cleavage or repression

9

What are the three major types of cytoskeletal proteins

Actin microfilaments, intermediate filaments, and microtubules

10

What type of receptor does TGF Beta bind to

Type 1 and 2, both are serine/threonine kinases

11

LDL and transferrin intake uses which kind of endocytosis

Clatharin coat dependent intake, fusion with lysosome, and is then recycled

12

What part of the genome codes fro the architectural planning

Noncoding region

13

What amino acid does histone acetylation occur

Lysine

14

What are the characteristics of SNPs

Single nucleotide position variations and biallelic (two choices)

15

Where is phosphatidylinositol located and what is its purpose

Inner leaflet of membrane
Serves as a scaffolding and can be hydrolyzed by phospholipase C for second messaging

16

What is the association of soluble VEGFR1 excess in pregnant women

Causes preeclampsia and hypertension
(Due to “taking up” free VEGF which would help to maintain the endothelium of blood vessels

17

What are the causes of weak connective tissues

Defects in primary sequence, procollagen endopetidase processing, hydroxylation, or cross linking

18

What percent of proteins are involved in oxidative phosphorylation are coded by the mitos

20%

19

What are three receptors that have no intrinsic catalytic activity and what is the protein that does it

Integrins, immune receptors, cytokine receptors by nonreceptor tyrosine kinase

20

What is the characteristic of the euchromatin

Disperse (unwound) and active

21

What is the transcription factor assocaited with growth arrest

P53

22

What are N linked oligosaccharides

Sugar moietites attached to aspartate residues

23

What is the charge of the proteoglycan bristles

Negative charge

24

What percent of the human genome codes for proteins

1.5%

25

What is the general function of platelet derived growth factor (PDGF)

Chemotactic for inflammation cells (macros, neutros, fibroblasts) into site of injury. Also for muscle cells

26

What are the major components of basement membrane

Amorphous nonfibrillar Type 4 collagen and laminin

27

Where are proteins that lack signal sequences translated

Free ribosomes in the cytoplasm

28

What are the characteristics of the carrier proteins

Bind specific solutes and undergo conformational changes to transport ligand across membrane

29

What is the function of vascular endothelial growth factor -C&D(VEGF-C&D)

Stimulate angiogenesis and lymphatic development

30

What percent of human genome either binds proteins, regulating gene expression or some other function

85%