Chapter 6- Hypersensitivity Disorders Flashcards Preview

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Flashcards in Chapter 6- Hypersensitivity Disorders Deck (82)
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1

What is the mechanism of disease in IBD

Inflammation via Th1 and 17 cytokines

2

What is the mechanism of disease in contact sensitivity

Th1 cytokines

3

What type of hypersensitivity is pernicious anemia

Type 2

4

What is the clinical presentation of contact sensitivity

Epidermal necrosis, dermal inflammation, skin rash and blisters

5

What type of hypersensitivity is SLE

Type 3

6

What is the target antigen of Graves’ disease

TSH receptors

7

What is the clinical presentation of serum sickness

Arthritis, vasculitis, nephritis

8

What is the clinical presentation of pernicious anemia

Abnormal erythropoiesis, anemia

9

What is the mechanism of disease in autoimmune thrombocytopenia purpura

Opsonization and phagocytosis of platelets

10

What is the target antigen in contact sensitivity

Environmental antigens (poison ivy)

11

What is the mechanism of disease in pernicious anemia

Neutralization of intrinsic factor, leading to decreased absorption of B12

12

What is the clinical presentation of Graves’ disease

Hyperthyroidism

13

What type of hypersensitivity is IBD

Type 4

14

What is the clinical presentation of psoriasis

Destructive plaques in the skin

15

What type of hypersensitivity is Rheymatoid arthritis

Type 4

16

What is the clinical presentation of pemphigus vulgaris

Skin vesicles (bullae)

17

What is the target antigen in Rheymatoid arthritis

Collagen, citrullinated self proteins

18

What is the target antigen in Myasthenia gravis

ACh receptors

19

What is the target antigen in goodpasture syndrome

Noncollagenous proteins in basement membranes of kidney glomeruli and lung alveoli

20

What type of hypersensitivity is autoimmune thrombocytopenia purpura

Type 2

21

What type of hypersensitivity is pemphigus vulgaris

Type 2

22

What is the clinical presentation of autoimmune hemolytic anemia

Hemolysis, anemia

23

What type of hypersensitivity is Reactive arthritis

Type 3

24

What is the mechanism of disease in psoriasis

Inflammation via TH1 and 17 cytokines

25

What type of hypersensitivity is acute rheumatic fever

Type 2

26

What is the the target antigen in autoimmune thrombocytopenia purpura

Platelet membrane proteins (Gp2b:3a integrins)

27

What is the target antigen in Reactive arthritis

Bacterial antigen (Yersinia)

28

What type of hypersensitivity is insulin resistant diabetes

Type 2

29

What type of hypersensitivity is psoriasis

Type 4

30

What is the target antigen in acute rheumatic fever

Streptococcal cell wall antigen, which reacts with cardiomyocytes