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Robbins Pathology MOD1 (Chptr 1-6) > Chapter 6- Hypersensitivity Disorders > Flashcards

Chapter 6- Hypersensitivity Disorders Flashcards

(82 cards)

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1
Q

What is the mechanism of disease in IBD

A

Inflammation via Th1 and 17 cytokines

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2
Q

What is the mechanism of disease in contact sensitivity

A

Th1 cytokines

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3
Q

What type of hypersensitivity is pernicious anemia

A

Type 2

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4
Q

What is the clinical presentation of contact sensitivity

A

Epidermal necrosis, dermal inflammation, skin rash and blisters

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5
Q

What type of hypersensitivity is SLE

A

Type 3

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6
Q

What is the target antigen of Graves’ disease

A

TSH receptors

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7
Q

What is the clinical presentation of serum sickness

A

Arthritis, vasculitis, nephritis

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8
Q

What is the clinical presentation of pernicious anemia

A

Abnormal erythropoiesis, anemia

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9
Q

What is the mechanism of disease in autoimmune thrombocytopenia purpura

A

Opsonization and phagocytosis of platelets

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10
Q

What is the target antigen in contact sensitivity

A

Environmental antigens (poison ivy)

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11
Q

What is the mechanism of disease in pernicious anemia

A

Neutralization of intrinsic factor, leading to decreased absorption of B12

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12
Q

What is the clinical presentation of Graves’ disease

A

Hyperthyroidism

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13
Q

What type of hypersensitivity is IBD

A

Type 4

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14
Q

What is the clinical presentation of psoriasis

A

Destructive plaques in the skin

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15
Q

What type of hypersensitivity is Rheymatoid arthritis

A

Type 4

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16
Q

What is the clinical presentation of pemphigus vulgaris

A

Skin vesicles (bullae)

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17
Q

What is the target antigen in Rheymatoid arthritis

A

Collagen, citrullinated self proteins

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18
Q

What is the target antigen in Myasthenia gravis

A

ACh receptors

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19
Q

What is the target antigen in goodpasture syndrome

A

Noncollagenous proteins in basement membranes of kidney glomeruli and lung alveoli

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20
Q

What type of hypersensitivity is autoimmune thrombocytopenia purpura

A

Type 2

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21
Q

What type of hypersensitivity is pemphigus vulgaris

A

Type 2

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22
Q

What is the clinical presentation of autoimmune hemolytic anemia

A

Hemolysis, anemia

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23
Q

What type of hypersensitivity is Reactive arthritis

A

Type 3

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24
Q

What is the mechanism of disease in psoriasis

A

Inflammation via TH1 and 17 cytokines

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25
What type of hypersensitivity is acute rheumatic fever
Type 2
26
What is the the target antigen in autoimmune thrombocytopenia purpura
Platelet membrane proteins (Gp2b:3a integrins)
27
What is the target antigen in Reactive arthritis
Bacterial antigen (Yersinia)
28
What type of hypersensitivity is insulin resistant diabetes
Type 2
29
What type of hypersensitivity is psoriasis
Type 4
30
What is the target antigen in acute rheumatic fever
Streptococcal cell wall antigen, which reacts with cardiomyocytes
31
What type of hypersensitivity is polyarteritis nodosa
Type 3
32
What type of hypersensitivity is Graves’ disease
Type 2
33
What is the mechanism of disease in goodpasture syndrome
Complement and Fc mediated inflammation
34
What is the mechanism of disease in vasculitis caused by ANCA
Neutrophil degranulation and inflammation
35
What is the target antigen in Arthus reaction
Various foreign proteins
36
What is the target antigen in vasculitis caused by ANCA
Neutrophil granule proteins, causing their release
37
What is the clinical presentation in Reactive arthritis
Acute arthritis
38
What is the mechanism of disease in Rheymatoid arthritis
Inflammation from Th1 and 17 cytokines
39
What is the clinical presentation of vasculitis caused by ANCA
Vasculitis
40
What is the clinical presentation of polyarteritis nodosa
Systemic vasculitis
41
What is the clinical presentation of goodpasture syndrome
Nephritis, lung hemorrhage
42
What is the target antigen in pemphigus vulgaris
Proteins in the intracellular junctions of epidermal cells (epidermal Cadherins)
43
What type of hypersensitivity is goodpasture’s
Type 2
44
What is the mechanism of disease in insulin resistant diabetes
Antibody inhibition of Insulin binding
45
What is the clinical presentation of Arthus reaction
Cutaneous vasculitis
46
What type of hypersensitivity is MS
Type 4
47
What type of hypersensitivity is serum sickness
Type 3
48
What type of hypersensitivity is is poststreptococcal glomerulonephritis
Type 3
49
What type of hypersensitivity is Myasthenia gravis
Type 2
50
What is the mechanism of disease in acute rheumatic fever
Inflammation, macrophage activation
51
What is the mechanism of disease in pemphigus vulgaris
Antibody mediated activation of proteases leading to disruption of intercellular adhesions
52
What type of hypersensitivity is autoimmune hemolytic anemia
Type 2
53
What is the target antigen in autoimmune hemolytic anemia
RBC membrane proteins (Rh, blood type)
54
What is the clinical presentation of insulin resistant diabetes
Hyperglycemia, ketoacidosis
55
What is the target antigen of insulin resistant diabetes
Insulin receptor
56
What is the target antigen in poststreptococcal glomerulonephritis
Streptococcal cell wall antigens
57
What is the target antigen in SLE
Nuclear antigens
58
What is the clinical presentation of Rheymatoid arthritis
Chronic arthritis with inflammation, destruction of articular cartilage
59
What type of hypersensitivity is vasculitis caused by ANCA
Type 2
60
What is the target antigen in pernicious anemia
Intrinsic factor in gastric parietal cells
61
What is the clinical presentation of autoimmune thrombocytopenia purpura
Bleeding
62
What type of hypersensitivity is the Arthus reaction
Type 3
63
What type of hypersensitivity is contact sensitivity
Type 4
64
What is the target antigen in IBD
Enteric bacteria
65
What is the clinical presentation in MS
Demyelination of CNS with perivascular inflammation, paralysis
66
What type of hypersensitivity is Type 1 diabetes
Type 4
67
What is the clinical presentation of IBD
Chronic intestinal inflammation and obstruction
68
What is the target antigen in psoriasis
Unknown
69
What is the target antigen in Type 1 diabetes
Antigens of pancreatic islet B cels (insulin, glutamic acid decarboxylase)
70
What is the target antigen in polyarteritis nodosa
Hep B virus antigens
71
What is the clinical presentation of Type 1 diabetes
Insulitis (inflammation of islets), destruction of B cells
72
What is the clinical presentation in poststreptococcal glomerulonephritis
Nephritis
73
What is the mechanism of disease in MS
Inflammation via Th1 AND 17, myeine destruction via macrophages
74
What is the target antigen in MS
Protein antigens in myelin (myelin basic protein)
75
What is the mechanism of disease in Graves’ disease
Antibody mediated stimulation of TSH receptors
76
What is the target antigen in serum sickness
Proteins from foreign serum (horse antithymocyte globulin)
77
What is the clinical presentation of Myasthenia gravis
Muscle weakness, paralysis
78
What are the clinical presentations of SLE
Nephritis, skin lesions, arthritis, others
79
What is the mechanism of disease in Type 1 diabetes
T cell mediated inflammation, destruction via CTL
80
What is the mechanism of disease in autoimmune hemolytic anemia
Opsonization and phagocytosis of RBCs
81
What is the mechanism of disease in Myasthenia gravis
Ab inhibits ACh binding to receptors, down regulates receptor levels
82
What is the clinical presentation of acute rheumatic fever
Myocarditis, arthritis

Robbins Pathology MOD1 (Chptr 1-6) (10 decks)

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