Chapter 6- SLE and autoimmune dieases Flashcards Preview

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Flashcards in Chapter 6- SLE and autoimmune dieases Deck (105)
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1

What condition regarding the esophagus is common in scleroderma

Dysphagia due to esophageal fibrosis, in almost 50% of patients

2

What are the characteristics of type 3 renal lesions aka focal lupus nephritis

Involvement of less that 50% of all glomeruli
-Red cell casts in the urine

3

What are the diagnostic antibodies in SLE

Antibodies to dsDNA and Smith (sm) antigens

4

What is polyarteritis nodosa characterized by

Necrotizing inflammation of the walls of blood vessels

5

Patients with high titers of SS-A are more likely to what

Early Sjogren syndrome onset, longer disease duration, and extraglandular manifestations, such as cutaneous vasculitis and nephritis

6

What is the percent of cardiac involvement in SLE

50% of pts

7

What are the characteristics of class 2 renal lesion aka mesangial proliferative lupus nephritis

-masangial proliferation and accumulation of matrix
-Deposits of Igs and complement without involvement of glomerular capillaries

8

What are the most common causes of death in SLE patients

Renal failure and inter current infections

9

Specifically, what are the antibodies in SLE against

Antinuclear antibodies (ANA)

10

Which antibodies are commonly found in patients with Sjogren syndrome

Antibodies against two ribonucleoprotiens, SS-A (Ro) and SS-B (La)

11

What is the epidemiology of scleroderma

3:1 female to male ratio, with peak in 50-60

12

Which disease is sicca disorder associated with

Aka Sjogren syndrome, and is assocaited with RA

13

What percent of lung presentation is seen in SLE

50% of pts have pleuritis or pleural effusion

14

What is keratoconjunctivitis sicca

Dry eye

15

What is assocaited with scleroderma (systemic sclerosis) early in the course presentation

Vascular damage, especially microvascular

16

What is the changes seen in skin during scleroderma (systemic sclerosis)

Diffuse atrophy of skin, beginning in the fingers and distal regions

17

How does lupus antibodies affect clotting time

In Vitro, it will increase the PTT timing

18

What are the complications of mixed connective tissue disease

Pulmonary hypertension, interstitial lung disease, renal disease

19

What is the most prominent renal abnormality in scleroderma

Vascular lesion and interlobular arteries show thickening due to fibrosis

20

What is the percentage of scleroderma patients that have renal involvement

2/3

21

What is xerostoma

Dry mouth

22

What is the characteristic of joints in SLE

Nonerosive synovitis with little deformity (as opposed to RA)

23

Which HLA is more common to form a reaction following administration of hydralazine

HLA-DR4

24

Which HLA is more common to form a reaction following administration of Procainamide

HLA-DR6

25

What is the skin presentation in SLE

Butterfly rash (50% of pts)
-Urticaria, bullae, maculopapular lesions, ulceration

26

What are possible effects of the changes to esophagus in scleroderma

GERD and subsequent Barrett’s metaplasia

27

What is libman sacks endocarditis

Aka valvular endocarditis

28

What is limited scleroderma

Skin involvement and confined to fingers, forearms, and face

29

What are the four categories of antinuclear antibodies (ANAs)

1) antiDNA
2) Antihistone
3) anti nonhistone proteins attached to RNA
4) Antinucleolar antigens

30

Patients with scleroderma and anti topoisomerase antibodies (anti-Scl-70) are more likely to develop which condition

Pulmonary fibrosis and peripheral vascular disease