Chapter 65: ADHD Flashcards

(57 cards)

1
Q

What do stimulant medications raise in the treatment of ADHD?

A

Dopamine and NE

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2
Q

What is the first-line treatment for pre-school aged children (age 4-5 years)?

A

Parent training in behavior management and/or behavioral classroom intervention

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3
Q

ADHD medications are considered first-line in patients older than how many years?

A

6

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4
Q

What are the DSM-5 diagnostic criteria for inattention?

A

6+ symptoms of inattention for children up to age 16, OR 5+ symptoms for ages 17 and older. Symptoms must have been present for at least 6 months.

Fails to pay attention, trouble holding attention, does not pay attention when someone is talking, does not follow through on instructions, fails to finish schoolwork, has difficulty organizing tasks, avoids or dislikes tasks which require mental effort, loses things, is easily distracted and is forgetful.

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5
Q

What are the DSM-5 diagnostic criteria for hyperactivity and impulsivity?

A

6+ symptoms of hyperactivity-impulsivity for children up to age 16, OR 5+ symptoms for ages 17 and older. Symptoms must have been present for at least 6 months.

Often fidgets or squirms, leaves seat unexpectedly, runs about when not appropriate, unable to play quietly, is “on the go” as if “driven by a motor,” talks excessively, blurts out answers, has trouble waiting his/her turn and interrupts or intrudes on others.

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6
Q

Which conditions must be met in order to be diagnosed with ADHD?

A

Several inattentive or hyperactive-impulsive symptoms were present before the age of 12, symptoms must have been present in 2 or more settings (e.g., at home, school, work, with friends or relatives, babysitters), symptoms interfere with functioning, and are not caused by another disorder.

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7
Q

Which natural product is used for a variety of psych conditions and has shown to modestly improve cognitive function and behavior in children with ADHD?

A

Fish oils

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8
Q

What natural product can be taken to help with sleep onset in individuals taking stimulants?

A

Melatonin

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9
Q

What formulation of stimulants are preferred for children who would otherwise need a dose during the day at school?

A

Long-acting

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10
Q

A child or person who cannot swallow capsules or tablets can use these long-acting stimulant formulations:

A

Capsule, Chewable tablet, ODT, Patch, Suspension

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11
Q

Which stimulant capsules can be opened and sprinkled on a small amount of applesauce?

A

Adderall XR, Ritalin LA

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12
Q

Which stimulant medication can be opened and mixed in water, orange juice, or yogurt?

A

Vyvanse capsule

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13
Q

True or False: You can warm the food when sprinkling capsule contents, but you must take it right away.

A

False - do NOT warm the food

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14
Q

Which medication can be used first line when prescribers are concerned about the possibility of abuse by the patient or family?

A

Atomoxetine (Strattera)

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15
Q

Which non-stimulant medication can be tried when stimulants do not work well enough after a trial of 2-3 medications?

A

Atomoxetine (Strattera)

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16
Q

Which medications can be taken to help sleep while taking stimulants?

A

Clonidine IR (Catapres), diphenhydramine (OTC, 25-50 mg), melatonin (OTC, 2-5 mg)

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17
Q

Do not use stimulants within ___ days of ____

A

14 days of MAOi

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18
Q

What causes the increased HR and BP in patients taking stimulants?

A

Increased levels of DA and NE. Assess for cardiac disease at baseline

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19
Q

What other vascular problems can occur when taking stimulants?

A

Priapism and Raynaud’s disease

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20
Q

What can stimulants cause when used with other serotonergic drugs?

A

Serotonin syndrome

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21
Q

What is a common side effect of stimulants related to appetite?

A

Loss of appetite

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22
Q

How can loss of appetite from stimulants affect children?

A

It can contribute to a decrease in growth trajectory

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23
Q

What is the mechanism of action (MOA) of stimulants?

A

Block the reuptake of NE and DA

24
Q

How often can stimulant doses be titrated up to reduce adverse events?

25
True or False: Stimulants do not need to be tapered off when used as directed.
True
26
What is the brand name for methylphenidate IR tablet?
Ritalin
27
What is the dose for methylphenidate IR tablet?
5 mg BID 30 min before breakfast and lunch
28
What is the brand name for methylphenidate ER tablet?
Concerta (OROS delivery)
29
What is the dose for methylphenidate ER tablet?
18-36 mg QAM
30
What are the brand names for methylphenidate ER capsule?
Ritalin LA, Jornay PM
31
What is the brand name for methylphenidate TD patch?
Daytrana
32
What are the side effects of stimulants?
Insomnia, decreased appetite/weight loss, HA, irritability, N/V, blurry vision, dry mouth
33
What monitoring is required for stimulants?
Consider ECG prior to treatment; BP and HR, height and weight (in children)
34
What are the counseling points for Concerta OROS delivery?
The outer coat dissolves fast to give immediate action, and the rest is released slowly. Can see a ghost tablet in the stool; harder to crush which decreases abuse potential.
35
When should Daytrana be applied for desired effect and when should it be removed?
2 hours before desired effect and remove 9 hours after
36
Where should the Daytrana patch be placed?
Hips; alternate daily
37
Brand name for dextroamphetamine/amphetamine IR tablet
Adderall
38
Brand name for dextroamphetamine/amphetamine ER capsules
Adderall XR
39
What formulations does lisdexamfetamine come in
capsule and chewable tablet
40
Brand name for lisdexamfetamine
Vyvanse
41
T/F: lisdexamfetamine has a similar abuse potential to other stimulants
False - low abuse potential
42
Drug class of atomoxetine
SNRI
43
Brand name of atomoxetine
Strattera
44
Atomoxetine boxed warning
risk of suicide ideation
45
Atomoxetine contraindication
MAOi use within the past 14 days
46
Atomoxetine side effects
decreased appetite, insomnia, somnolence, dry mouth, HTN, tachycardia
47
T/F: you can open the capsule for atomoxetine
False ## Footnote capsules contain an ocular irritant
48
Brand name for clonidine ER tablet
Kapvay
49
Brand name for clonidine IR tablet (used for hypertension)
Catapres
50
Brand name for guanfacine ER tablet
Intuniv
51
When is clonidine dosed for ADHD?
QHS
52
How is guanfacine dosed?
daily then increased to weekly
53
Why should central alpha-2A Adrenergic agonists like guanfacine and clonidine not be d/c abruptly?
can cause rebound hypertension
54
Warnings for central alpha-2A Adrenergic agonists like guanfacine and clonidine?
dose-dependent CV effects, sedation and drowsiness
55
T/F: central alpha-2A Adrenergic agonists like guanfacine and clonidine do not need to be tapered?
False
56
What should be done to clonidine dose if used with strong CYP3A4 inducers?
Double the dose of clonidine
57
What should be done to clonidine dose if used with strong CYP3A4 inhibitors?
Decrease the dose by 50%