Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BSAVA Clinical Pathology > Chapter 7 > Flashcards

Chapter 7 Flashcards

1
Q

What are the constituents of plasma proteins?

A

Albumin, globulin, fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What are the constituents of serum proteins?

A

Albumin, globulin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What falsely increases measurement of total solids?

A

Haemolysis
Lipaemia
Colloids
Hyperglycaemia
Azotaemia
^Na
^Cl
^Bil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What peaks are seen on SPE and what accounts for them?

A

Albumin
Alpha-globulins - a-antitrypsin, a-acid glycoprotein, a macroglubulin, ceruloplasmin, protein C, haptoglobin, a-lipoproteins
Beta globulins - fibrinogen, complement, CRP, ferritin, transferrin, IgA, IgM
Gamma globulins - Ig@, IgG, CRP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is a final diagnosis of multiple myeloma reached in dogs?

A

3/4 of the following criteria:
Plasma cell infiltration of BM
Monoclonal gammopathy
Bony lytic lesions
BJ proteinuria

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

How does the presentation of multiple myeloma differ in cats?

A

Myeloma-related disorder
Monoclonal of biclonal gammopathy
Extramedullary involvement common (eg liver, spleen)
Lytic bone lesions uncommon
Bone marrow involvement in <50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

How common is hypercalcaemia in multiple myeloma?

A

10-20%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What neoplasia other than multiple myeloma is associated with hyperglobulinaemia?

A

Waldenstrom’s macroglobulinaemia
Proliferation of lymphoplasmacytoid cells with small proportion plasma cells
IgM gammopathy - hyper viscosity common

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Overproduction of which immunoglobulin is particularly associated with hyper viscosity?

A

IgM (largest)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Ddx for reduced albumin and globulin

A

PLE
Haemorrhage
Dermal loss
Septic peritonitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Which breeds are overrepresented for lymphangiectasia?

A

Yorkshire Terriers
Norwegian Lundehunds
Soft Coated Wheaten Terriers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What breeds are overrepresented for IgA deficiency?
How do they present?

A

Beagles, GSDs, Shar Pei
Recurrent skin, urinary or respiratory infections

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What breeds are overrepresented for IgG deficiency?
How do they present?

A

Weimaraners
Recurrent infections with left shift and poor response to treatment

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What breeds are predisposed to X-linked combined immunodeficiency (X-SCID)?

A

Bassett Hounds and Corgi’s

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What are the major, moderate and negative APPs in dogs?

A

Major - CRP, SAA
Moderate - Haptoglobulin, AGP, ceruloplasmin
Negative - Albumin, transferrin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What are the major, moderate and negative APPs in cats?

A

Major - SAA, AGP
Moderate - Haptoglobulin
Negative - Albumin, transferrin

17
Q

What is the main limitation of measuring haptoglobin?

A

Production increased by steroids (exogenous and endogenous)

18
Q

Which APPs reduce in response to treating HAC in dogs?

A

Haptoglobin and SAA

BSAVA Clinical Pathology (25 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions