Chemotherapy

Question 1

What does transglycosylase do?

Answer 1

Crosslinks glycan strands and extends chains

Question 2

What does transpeptidase do?

Answer 2

Crosslinks peptide strands

Question 3

What does bactoprenol do?

Answer 3

Forms phosphate bridge with the cell wall precursor so it can be transported to teh outer membrane

Question 4

What kind of hydrolases are transpeptidases?

Answer 4

Serine hydrolases

Question 5

Which are the aminoglycosides?

Answer 5

Streptomycin and gentamycin

Question 6

Which is the macrolide?

Answer 6

Erythromycin

Question 7

Which are 30S subunit?

Answer 7

Tetracycline and streptomycin

Question 8

Which are 50S subunit?

Answer 8

Chloramphenicol and erythromycin

Question 9

Which bacteria are aminoglycosides inhibited in?

Answer 9

Gram -ves

Question 10

What is chloramphenicol used to treat?

Answer 10

Typhus and bacterial meningitis from H influenzae or N meningitidis

Question 11

What does fusidic acid used for?

Answer 11

Skin and eye infections by gram +ves

Question 12

Which infections are fluoroquinolones used against?

Answer 12

UTIs, osteomyelitis, pneumonia, gastroenteritis, anthrax and pseudomonas

Question 13

What is rifampin used to treat?

Answer 13

TB

Question 14

What is co-trimoxazole used to treat?

Answer 14

Pneumocystis

Question 15

What is polymixin used to treat?

Answer 15

Resistant pseudomonas

Question 16

What is amphotericin B active against?

Answer 16

Cryptococcus, aspergillus, candida

Question 17

What is melarsen used to treat?

Answer 17

Trypanosoma

Question 18

What is suramin used to treat?

Answer 18

Trypanosoma

Question 19

What does sodium stibogluconate treat?

Answer 19

Leishmaniasis

Question 20

What is fansidar used against?

Answer 20

Plasmodium

Question 21

What is IFN-alpha-2a used to treat?

Answer 21

HBV and AIDS Kaposi sarcomas

Question 22

What is IFN-alpha-2b used to treat?

Answer 22

HCV

Question 23

Which receptors do IFNs act on?

Answer 23

Ganglioside

Question 24

Which active site do A C and D have?

Answer 24

Serine

Question 25

What do B lactamases do?

Answer 25

Use zinc to activate a water molecule and add it to the ring

Question 26

What are vancomycin resistant bacteria called?

Answer 26

VanA and VanB

Question 27

Which enzymes do vancomycin resistant bacteria have?

Answer 27

VanH, VanA and VanX

Question 28

Which proteins do vancomycin resistant bacteria have?

Answer 28

VanS and VanR

Question 29

Which bacteria has lots of efflux transporters?

Answer 29

Pseudomonas

Question 30

Which regulon controls MDR in E coli?

Answer 30

MAR

Question 31

What makes up HAART?

Answer 31

Protease inhibitor + reverse transcriptase inhibitor

Question 32

What shows the points where drug efficacies overlap?

Answer 32

Isobologram

Question 33

What is dose proportional to with new anticancer agents?

Answer 33

Body surface area

Question 34

What is a phase II trial?

Answer 34

Anti-tumour efficacy

Question 35

What is a phase III trial?

Answer 35

Comparison with best available therapy