Anthelmintics Flashcards
Which are the inhibitory ligand gates channels?
GABA-R, Glu-R and SLO-1
What does Glu-R let in?
Chloride
What is the latrophilin receptor permeable to?
Ca2+
What is sweet itch?
Type I hypersensitivity to midge saliva
Where does demodex live?
Hair follice
Where is an acaricide active against?
Ticks and mites
What is an insecticide active against?
Insects
How to contact poisons pass through ectoskeleton?
Between chitin plates
Where are inhibitory glutamate Cl- channels found?
Pharynx and egg laying muscles
What do cysteine proteases do?
Break down collagen by hydrolysing peptide bond and reducing egg production
How many helminth AChE gene are there?
3
What does SLO-1 activation presynaptically cause?
Hyperpolarisation so no transmission
What does SLO-1 activation post-synaptically do?
Hyperpolarisation
What are the two types of inhibitory hyperpolarising K+ channels?
One Ca2+ activated and one like the SLO channel
What does the LLR do?
Hyperpolarises post-synaptic membrane
What is a nematode?
Round worm
What is a trematode?
FLuke
What is a cestode?
Tape worm
What are the three types of AChE in a helminth?
1,2,3
How does glutamate cause its inhibitory effect?
Acts on LLR GPCR, activates PLC, makes DAG/IP3, activates UNCI3 and synaptobrevin, causes neurotransmitter release which hyperpolarises post synaptic membrane
How do pyrethroids work?
Excitotoxin - delay opening and closing of Na+ channel
Which pyrethroids degreade in sunlight?
Type I
What must pyrethroids be synergised with?
BPO
What does piperonl butoxide do?
Type I pyrexin potentiator
