Choudhury III Flashcards Preview

Year2 GI Exam I > Choudhury III > Flashcards

Flashcards in Choudhury III Deck (34)
1

what are the cells in the pancreas

ductal and acinar cells

2

describe acinar and ductal secretions from pancreas

acinar are enzyme rich
ductal are HCO3 rich and neutralized acidic chyme

3

chyme entering duodenuma causes what

duodenal enterendocrin cells to release CCK and secretin

4

What is role of CCK

induces secretion of enzyme rich pancreatic juice
causes gall bladder to contract and hepatopancreatic sphincter to relax so bile enters duodenum
reduced emptying in stomach

5

role of secretin

secretion of HCO3 rich pancreatic juice

6

during what phases does the vagus nerve cause gall bladder to contract

cephalic and gastric

7

What does enteropeptidase activate

trypsinogen to trypsin

8

what does trypsin activate

chymotrypsinogen to chymotrypsins
proelastase to elastase
procarboxypeptidase A to carboxypeptidase A
and proc B to cB
also activates PLA2

9

what protects pancreas from prematurely activated enzymes

protease inhibitors that are within the zymogen granules

10

What controls CCK release?

CCK-releasing peptide and monitor peptide

11

what cell release CCK

I cells

12

what inhibits CCK release

trypsin

13

what releases secretin

S cells in duodenal mucosa

14

at high rates of secretion what is content of pancreatic secretions

much more Cl andHCO3
not Na and H
(alkaline)

15

When pH falls in duodenum what is response

S cells secrete secretin

16

fatty acid meals evoke release of what

secretin

17

what is achlorhydria

unable to secrete gastric acid

18

secretin levels in achlorhydria

low

19

at what percent of pancreatic secretion will there be signs of malabsoprtion and indigestion

less than 10%

20

most common causes pancreatitis

alcohol abuse and gallstones

21

how can CF lead to pancreatic insufficiency

thick secretions can obstruct pancreatic duct

22

what is a key clinical sign of pancreatic insufficiency

steatorrhea
floating feces, oily appearance and foul smelling

23

what is a hereditary cause of pancreatitis

mutated trypsin that makes it resistant to inhibitors
tryspin eats pancreatic tissue

24

what drugs can cause pancreatitis

immunosuppressants, anticonvulsants, thiazides

25

what genetic abnormalities may lead to pancreatitis

SPINK1, CFTR, CTRC

26

saliva conent in primary aldosteronisms

NaCl zero
K increases to high levels

27

What is impaired in kwashiorkor

protein digestion

28

what enzymes are found in brushborder of small intestine epithelial cells

maltase, lactase, sucrase

29

how are glucose and galactose absorbed in intestines

Na ATP dependent secondary active transport
Na/glucose co transporter

30

how is fructose absorbed

passive facilitated diffusion

31

maltose is made up of what?
sucrose?
lactose?

maltose= 2 glucose
sucrose= 1 glucose, 1 fructose
lactose= 1 galactose, 1 glucose

32

how are aminoacids and polypeptides transported across basolateral membrane of enterocytes

facilitated or simple diffusion

33

how is fat absorbed (general)

broken down then rebuilt in cell and transported as chylomicrons

34

what displaces bile salt molecule from fat-water interface

colipase