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Year2 GI Exam I > IBS Tx > Flashcards

Flashcards in IBS Tx Deck (18)
1

What is IBS

idiopathic chronic disorder with abdominal discomfort, pain, bloating, distention or cramps in association with diarrhea, constipation or both

2

goals therapy IBS

relieve abdominal pain and discomfort and improve bowel function

3

what are the important first steps in management of IBS

patient counseling and dietary change

4

what is used for IBS with predominant diarrhea

loperamide

5

Tx for IBS predominant constipation

osmotic laxatives

6

what is used to Tx chronic abdominal pain in IBS patients

low dose tricyclic antidepressants like amitryptyline

7

what is the prototype for a serotonin partial agonist

tegaserod
available in restricted program form increase risk in ischemic events

8

what is the prototype of 5-HT3 R antagonist

alosetron- restricted use program

9

what are the other serotonin antagonists on market

ondansetron, granisetron, dolasetron, palonosetron

10

MOA serotonin antagonists

inhibits GI afferent R reducing unpleasant sensations
blocks central R reducing visceral afferent stimulation-- inhibits colonic motility, increasing transit time

11

therapeutic use serotonin antagonists

women with severe diarrhea from IBS
efficacy in men not established
reduces lower abdominal pain,c ramps, urgency, diarrhea, decreases mean number bowel movements per day and improves stool consistency

12

adverse effects to serotonin antagonists

constipation

13

Drug interactions wiht serotonin antagonists

none

14

MOA antispasmotics used in IBS and what are drug names

dicyclomine and hyoscyamine
inhibit muscarininc cholinergic R in enteric plexus on smooth muscle
high does- excessive anticholinergic effects

15

What is prototype chloride channel activator in IBS

lubiprostone

16

MOA lubiprostone

stimulates type 2 Cl Ch in small intestine and stimulates secretion and dec transt time through small intestine and colon. delays gastric emptying which can cause anorexia and nausea

17

therapeutic use Cl Ch activator

women with constipation predominant IBS, efficacy in men unproven

18

adverse effects lubiprostone

nausea from delayed gastric emptying