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Year2 GI Exam I > Path VI > Flashcards

Flashcards in Path VI Deck (30)
1

type of microbe is salmonella

gram - bacilli

2

salmonella typhi causes what

thyphoid fever

3

when is peak incidenc of salmonella enteritis

summer and fall
contaminated foot like meat, poultry, eggs, milk

4

virulence factors salmonella

type III secretion system
allow growth in phagosomes
flagellin
activate TLR5
prevent TLR4 activation
attracts neutrophils

5

what immune response activates in salmonella

Th17

6

Sx salmnoella

fever, pain, diarrhea or dysentery

7

how does salmonella affect peyers patches

in terminal ileum to enlarge into plateau like elevations
neutrophils accumulate
mucosal shedding creates oval ulcers oriented along axis of ileum that may perforate

8

liver in typhoid fecter

typhoid nodules- amcrophage aggregates

9

clinical features typhoid fever

anorexia, abdominal pain, bloating, nausea, vomiting bloody diarrhea, flu like Sx from bacteremia
maculopapular lesions

10

result of cholera toxin

decrease in NaCl resorption
Cl HCO3 secretion

11

most comon bacterial enteritis in world

campylobacter enterocolitis

12

transmission campylobacter enterocolitis

chicken, milk, water

13

Sx campylobacter

flu like prodrome
arthritis, IBS
erythema nodosum

14

what cells take up shigella

M cells, Left colon

15

What is pseudomembranous colitis

adherent layer of inflammatory cells and debris over sites of mucosal injury

16

toxins from C difficile

A and B

17

Dx C difficile

detecting cytotoxin in stool

18

Whipple disease

chronic relapsing multisystem illness of GI tract, diarrhea, steatorrhea, malabsorption

19

Sx whipple disease

weight loss, diarrhea, polyarthritis

20

what cause whipple

tropheryma whipplei

21

whipple disease affects?

Whites 4-th-5th decades 10:1 male predominance

22

Tx whipple disease

antibiotics

23

source cryptosporidium spp

contaminated water

24

where does cryptosporidium spp concentrate

terminal ileum and right colon

25

diarrhea causing agents that affect AIDS

cryotosporidum, atypical mycobacteria, CMV

26

what parasites cause enterocolitis

nematodes, cestodes, trematodes, unicellular parasites

27

where to you transmit entamoeba histolytica

mature cysts in fecally contaminated food water or on hands

28

msot common pathogenic parasitic infection

giardia

29

3 clinical forms giardia

asymptomatic carrier w/ w/o Hx clinical disease
acute diarrhea
chronic GI disease with malabsopriong, recurrent diarrhea, with or w/o abdominal discomfort

30

where does giardia occur

child day care centers
developing countries