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Flashcards in Chronic Inflammation Deck (6)
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Macroscopic signs of chronic inflammation

1) Ongoing tissue repair and scarring

2) Firm swelling

3) Less redness

4) Less pain

5) Less heat


Microscopic signs of chronic inflammation

1) Accumulation of monocytes, macrophages, plasma cells

2) Destruction of normal tissue structures

3) Fibrosis (proliferation of fibroblasts and connective tissue)

4) Angiogenesis

5) Granulomas can form (macrophages around a center and surrounded by fibroblasts, lymphocytes, plasma cells)


Macrophage activation

TNFα from other macrophages

IFN-γ from natural killer (NK) cells


3 ways you get chronic inflammation

1) Persistent microbes

2) Genetic defects that lead to impaired resolution of inflammation

3) Occupational lung diseases



Aggregate of macrophages sometimes forming multinucleated giant cells, surrounded on outside by lymphocytes and plasma cells

To contain a microbe such as TB, or foreign material

Formation stimulated by IFN-γ and IL-12


When will eosinophils infiltrate tissue?


Allergic reaction

Parasitic (multicellular) infection

Eosinophils activated by IL-4, IL-5