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Flashcards in Phagocytes Deck (6):
1

What are phagocytes attracted by?

Stuff on microbes (formylated peptide)

Plasma proteins (complement)

Stuff released by epithelial cells or macrophages exposed to microbes (chemokines like IL-8, MCP)

Stuff released by macrophages and other inflammatory cells NOT exposed to microbes (lipid mediators like LTB4, PAF)

2


M1 Macrophage

Classically activated

Pro-inflammatory

Kills

3


M2 macrophage


Alternatively activated

Anti-inflammatory

Healing

4


Neutrophil arsenal


ROS

Nutrient binding proteins (lactoferrin to sequester iron from fungi!)

Proteases

Lysozymes

Microbicidal peptides (defensins and cathelicidins)

5


How are macrophages activated


INF-gamma released by lymphocytes

TNF-alpha from other macrophages

Note: you block TNF-alpha in rheumatoid arthritis pts to alleviate symptoms and their latent TB shows up because granulomas broken up

6

Eosinophils

SImilar to neutrophils: respiratory burst, phagocytic, 1 day lifespan

Different from neutrophils: bi-lobed, bigger granules, have different granule proteins, kill parasites, show up during allergic response