Innate Immunity Flashcards Preview

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Flashcards in Innate Immunity Deck (5):
1

Structures on pathogens that the innate immune system recognizes

Peptidoglycan (cell wall)

Teichoic acid (gram pos)

LPS (gram neg)

Lipopeptides (bacteria)

Flagella

Unmethylated CpG in DNA (bacteria)

dsRNA (in virus)

 

2

Proteins involved in recognizing microbial structures

1) TLRs

2) NOD-like receptors

3) Peptidoglycan-recognition proteins

4) Complement

3

NFκB stimulates transcription of what factors?

Adhesion molecules (ICAM, E-selectins)

Inflammatory cytokines (IL-1, IL-6, IL-8, IL-2, GM-CSF)

Anti-microbial peptides

iNOS (generates NO)

TNFα

INF-β

4


Endotoxin


Molecule on bacteria that is recognized by immune system

Ex: LPS

Associated with gram-negative bacteria

5

Innate Immunity


Physical barriers (skin, epithelia, mucosa)

Chemical barriers (antimicrobials in mucus)

Sensors of microbes and tissue injury

Phagocytes and NK cells

Complement