Chronic Kidney Disease Flashcards
(39 cards)
hematuria
Blood in urine
Azotemia
Toxins, lack of kidney filtration
oliguria
Decreased urine output
<400 ml/day
glomerular filtration rate
Lab that test amount of blood being filtered by glomeruli
kidney function
Maintain fluid and electrolyte homeostasis
Get rid of water, soluble waste via urine
Produces erythropoietin – RBC production
Activate vitamin D
Produces renin – regulates BP
Normal BUN level
10-20
normal Cr level
0.5-1.2
normal BUN/Cr
10:1
normal GFR
> 90 ml/min
chronic kidney disease
Presence of kidney damage >3 months with or without GFR <60
In ability to maintain acid base balance, remove end products of metabolism, maintain fluid/electrolyte balance
stage one of CKD
Kidney damage with normal or increased GFR
> = 90
symptoms of stage 1
Asymptomatic
Stage two of CKD
damage with mild, decreased GFR
60-89
symptoms of stage two
Asymptomatic, HTN, possibly
stage three of CKD
Moderate decrease GFR
30-59
symptoms of stage three
Hypertension
stage four of CKD
Severe decreased GFR
15-29
what stage of CKD are symptoms apparent?
Stage four
stage five of CKD
End stage renal failure
<15
symptoms of stage five
Uremia
Causes of end-stage renal disease
1 diabetes
HTN
Glomerular nephritis
risk factors of CKD
Family history
>60 yrs old
Male, AA
HTN, diabetes, smoking
Overweight, obese
pathogenesis of CKD
Glomerulosclerosis – scar tissue
Interstitial fibrosis
Interstitial inflammation
Complement – further destruction of kidney disease
Angiotensin II - increased BP
uremia
Retention of metabolic wastes
Urea, phenols, Cr, hormones, electrolytes, water
