Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

RENAL II Exam 3 > Chronic Renal Failure CIS > Flashcards

Chronic Renal Failure CIS Flashcards

(64 cards)

Start Studying
1
Q

stage 1 CKD

A

GFR > 90

*diabetics

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

stage 2 CKD

A

GFR 60-89

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

stage 3 CKD

A

GFR 30-59

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

chronic kidney disease**

A

stage 3 for 3 months

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

70% of CKD**

A

HTN or DM

then GN and cystic disease
then prostate and tubulointerstitial disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

important signs of CKD

A 
bone disease
anemia
broad waxy casts
paresthesias
bilateral small kidneys
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

decreased GFR causing HTN

A

decreased sodium > turns on sympathetics > turns on RAAS

therefore - get sodium and water retention

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

bone disease and CKD

A

PTH

  • normally inhibits P reabsorption and increases Ca reabsorption
  • CKD - no 1,25 hydrox of Vit D
  • decreased PTH and no Ca reabsorption
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

phosphate vs. calcium

A

decreased GFR

  • PTH can’t get rid of P
  • P goes up, and Ca goes down
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

decreased GFR and P/Ca

A

increased P and decreased Ca

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Vit D metabolism

A

1 hydrox - liver
25 hydrox - kidney (prox tub)

  • therefore don’t get Vit D
  • calcium low
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

low Ca

A

activates PTH release

  • increased osteoclast bone resorption
  • get osteitis fibrosia cystica
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

anemia and CKD

A

no erythropoietin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

isosthenuria

A

same concentrated urine

-with CKD

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

waxy broad casts

A

chronic renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

subepithelial deposit humps
IgG and C3
hematuria and RBC casts
complement low

A

immune complex disorder
-post-infectious GN

shunt -staph

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

synpharyngitic hematuria

A

same time as infection

post-strep week later**

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

mesangium

A

IgA nephropathy

-most common in world

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

prognosis with proteinuria?

A

more proteinuria - gets worse

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

bergers disease

A

IgA nephropathy

-IgA1 - galactose deficiency in O-linked glycans

diseases with altered IgA - hepatic cirrhosis, HIV, CMV, celiac disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

IgA nephropathy with arthralgia, nausea, colic, melena, rash

A

henoch-schonlein

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

heamturia, rash, P-ANCA, RBC casts

A

microscopic polyangitis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

P-ANCA

A 
microscopic polyangitis (churg strauss)
-no granulomatous inflammation and no upper resp involvement**
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

C-ANCA

A

granulomatosis with polyangitis

-wegeners

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
25
pauci immune
not immune complex -but instead neutrophil activation ANCA type**
26
formation of ANCAs
MPO - antibodies to strong cations - pANCA PR3 - antibodies to neutral/weak cations - cANCA
27
pANCA
anti-MPO - strong cations
28
cANCA
anti-PR3 - neutral/weak cations
29
anti-GMB disease
alpha 3 chain of type IV collagen
30
linear antibody deposition
goodpasture | or anti-GMB GN
31
hematuria, hepatosplenomegaly, cold night purpura, RBC casts, hep C positive
essential mixed cryoglobulinemia
32
cryoglobulinemia
hep C | -antibodies against antibodies
33
cold aggultinin
mycoplasm
34
type 1 cryoglobulinemia
cancers of blood and immune system
35
type 2 and 3 cryoglobulinemia
autoimmune diseases and viruses (Hep C)
36
ultimate causes of lots of disorders
malignancy autoimmune infection drugs
37
best initial treatment for most CKD patients
ACE inhibitors | -unless Cr over 3**
38
type I MPGN
subendo and subepi - complement low (C3 and C4)*** - tram-tracking typically with Hep C virus
39
type II MPGN
- complement normal | - dense deposit disease
40
Hep C virus**
1 type I MPGN (nephritic 2 mixed cryoglobulinemia (nephritic) 3 membranous nephropathy (nephrotic)
41
type II MPGN
dense deposit disease - alternate complement - C3 low, C4 normal*** - ribbon like deposits
42
low C3
type II MPGN
43
low C3 and C4
type I MPGN
44
Tx for nephritic
ACE (-)** - for proteinuria methylpredisolone for proteinuria > 1 g/day and GFR >70 cyclophosphamide for GFR <70 and prediction to ESRD within 5 years
45
black, HIV, heroin, HTN, periorbital edema, oval fat bodies
likely FSGS
46
FSGS
focal and segmental - polymorphisms in APOL1 gene (blacks) - C1q nephropathy HIV, heroin, obesity, UV reflux
47
lymphoma, edema, weight gain, recurrent infections, dyspnea, thickened GBM with spike and dome of subepithelial deposits
membranous GN
48
membranous GN
cause - lymphoma, carcinoma, PCN, gold, SLE, MCTD, thyroiditis, Hep B/C, endocarditis, syphilis IgG and C3 spike and dome subepithelial deposits
49
PLA2
hereditary membranous GN
50
alpha-1 antithrombin***
gets through the glomerulus - get clotting - nephrotic syndrome
51
nephrotic
loss of antithrombin III protein C protein S increased lipoprotein, fibrinogen, and platelet aggregation
52
causes of chronic tubulointerstitial disease**
proud american veterans love GM ``` prostate analgesics VUR lead gout myeloma ```
53
back pain and increased sed rate
multiple myeloma
54
non-anion gap acidosis**
hyperchloremic acidosis**
55
myeloma
can give you low anion gap
56
RTA type I
distal tubules -failure of H secretion by alpha intercalated cells urine pH >5.5 (cannot secrete protons to acidify urine) basic urine**
57
RTA type II
proximal | -failure of HCO3 reabsorption in prox tub
58
RTA type IV
adrenal -aldosterone deficiency get high potassium**
59
multiple myeloma
damage prox tubule | -RTA type II
60
causes of type I RTA**
ampoteracin B hyper PTH sjogrens distal tubule H secretion problems
61
causes of type II RTA**
myeloma protein, tenovofir, toluene, acetazolamide, toperimate, zonisamide
62
Cl/HCO3 relationship
Cl high - bicarb low >metabolic alkalosis
63
fanconi syndrome
bence jones proteins damaged prox tub and caused to leak HCO3
64
myeloma kidney
``` high Ca high uric amyloidosis B cell infiltrates hyperviscosity ```

RENAL II Exam 3 (17 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions