Chronic Renal Failure CIS Flashcards Preview

RENAL II Exam 3 > Chronic Renal Failure CIS > Flashcards

Flashcards in Chronic Renal Failure CIS Deck (64)
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1

stage 1 CKD

GFR > 90
*diabetics

2

stage 2 CKD

GFR 60-89

3

stage 3 CKD

GFR 30-59

4

chronic kidney disease**

stage 3 for 3 months

5

70% of CKD**

HTN or DM

then GN and cystic disease
then prostate and tubulointerstitial disease

6

important signs of CKD

bone disease
anemia
broad waxy casts
paresthesias
bilateral small kidneys

7

decreased GFR causing HTN

decreased sodium > turns on sympathetics > turns on RAAS

therefore - get sodium and water retention

8

bone disease and CKD

PTH
-normally inhibits P reabsorption and increases Ca reabsorption
-CKD - no 1,25 hydrox of Vit D
-decreased PTH and no Ca reabsorption

9

phosphate vs. calcium

decreased GFR
-PTH can't get rid of P
-P goes up, and Ca goes down

10

decreased GFR and P/Ca

increased P and decreased Ca

11

Vit D metabolism

1 hydrox - liver
25 hydrox - kidney (prox tub)

-therefore don't get Vit D
-calcium low

12

low Ca

activates PTH release
-increased osteoclast bone resorption
-get osteitis fibrosia cystica

13

anemia and CKD

no erythropoietin

14

isosthenuria

same concentrated urine
-with CKD

15

waxy broad casts

chronic renal disease

16

subepithelial deposit humps
IgG and C3
hematuria and RBC casts
complement low

immune complex disorder
-post-infectious GN

shunt -staph

17

synpharyngitic hematuria

same time as infection

post-strep week later**

18

mesangium

IgA nephropathy
-most common in world

19

prognosis with proteinuria?

more proteinuria - gets worse

20

bergers disease

IgA nephropathy

-IgA1 - galactose deficiency in O-linked glycans

diseases with altered IgA - hepatic cirrhosis, HIV, CMV, celiac disease

21

IgA nephropathy with arthralgia, nausea, colic, melena, rash

henoch-schonlein

22

heamturia, rash, P-ANCA, RBC casts

microscopic polyangitis

23

P-ANCA

microscopic polyangitis (churg strauss)
-no granulomatous inflammation and no upper resp involvement**

24

C-ANCA

granulomatosis with polyangitis
-wegeners

25

pauci immune

not immune complex
-but instead neutrophil activation

ANCA type**

26

formation of ANCAs

MPO - antibodies to strong cations - pANCA

PR3 - antibodies to neutral/weak cations - cANCA

27

pANCA

anti-MPO - strong cations

28

cANCA

anti-PR3 - neutral/weak cations

29

anti-GMB disease

alpha 3 chain of type IV collagen

30

linear antibody deposition

goodpasture
or anti-GMB GN