Intro to Antihypertensive Agents II Flashcards Preview

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Flashcards in Intro to Antihypertensive Agents II Deck (50)
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1

acetazolamide

carbonic anhydrase inhibitor

2

brinzolamide

carbonic anhydrase inhibitor

3

dorzolamide

carbonic anhydrase inhibitor

4

methazolamide

carbonic anhydrase inhibitor

5

furosemide

loop diuretic

lasix

6

ethacrynic acid

loop diuretic
-will not cause sulfa allergy**

7

bumetanidine

loop diuretic

8

torsemide

loop diuretic

9

HCTZ

thiazide diuretic

10

chlorothiazide

thiazide diuretic

11

hydroflumethiazide

thiazide diuretic

12

indapamide

thiazide diuretic

13

methylclothiazide

thiazide diuretic

14

metolazone

thiazide diuretic

15

polythiazide

thiazide diuretic

16

trichlormethiazide

thiazide diuretic

17

eplerenone

K sparing
-aldosterone antagonist

18

spironolactone

K sparing
-aldosterone antagonist

19

amiloride

K sparing
-ENaC inhibitor

20

triamterene

K sparing
-ENaC inhibitor

21

mannitol

aquaretic
-osmotic diuretic

22

isosorbide

aquaretic
-osmotic diuretic

23

conivaptan

aquaretic
-ADH antagonist

24

tolvaptan

aquaretic
-ADH antagonist

25

carbonic anhydrase inhibitors

-proximal convoluted tubule
-membrane bound and cytoplasmic forms of enzyme

-result in decreased H formation in cell
> decreased Na/H antiport
> increased Na and HCO3 in lumen
> increased diuresis

**urine pH increase and body pH decrease**

**hypokalemia, but metabolic acidosis**

26

indications for CAIs

rarely used - develop metabolic acidosis

-glaucoma, acute mountain sickness, metabolic alkalosis

27

adverse effects of CAIs

-acidosis
-hypokalemia
-renal stones
-paresthesias
-sulfonanide hypersensitivity

28

loop diuretics

-inhibit lumen Na/K/2Cl cotransporter in thick ascending limb

-increased lumen Na, K and Cl
>decreased back diffuse of K and positive potential in lumen
>decreased reabsorption of Ca and Mg
>diuresis

among most efficacious diuretics**

good for edematous states

29

loop diuretic activity

tied to secretion rate
-half life correlates to kidney function

-0.5-2 hours (healthy)
-9 hours (ESRD)

30

adverse effects of loop diuretics

hypokalemia, alkalosis, hypocalcemia, hypomagnesemia, hyperuricemia, ototoxicity, sulfonamide hypersensitivity (not all)