Intro to Antihypertensive Agents III Flashcards Preview

RENAL II Exam 3 > Intro to Antihypertensive Agents III > Flashcards

Flashcards in Intro to Antihypertensive Agents III Deck (46)
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1

benazepril

ACE inhibitor

2

captopril

ACE inhibitor

3

enalapril

ACE inhibitor

4

enalaprilat

ACE inhibitor
-active metabolite
-used in IV

5

fosinopril

ACE inhibitor

6

lisinopril

ACE inhibitor

7

moexipril

ACE inhibitor

8

perindopril

ACE inhibitor

9

quinapril

ACE inhibitor

10

ramipril

ACE inhibitor

11

trandolapril

ACE inhibitor

12

azilsartain

angiotensin receptor blocker

13

canesartan

angiotensin receptor blocker

14

eprosartan

angiotensin receptor blocker

15

irversartan

angiotensin receptor blocker

16

losartan

angiotensin receptor blocker

17

olmesartan

angiotensin receptor blocker

18

telmisartan

angiotensin receptor blocker

19

valsartan

angiotensin receptor blocker

20

clonidine

block renin secretion

21

propanolol

block renin secretion

22

aliskiren

renin inhibitor

23

renin

converts angiotensinogen to angiotensin I

24

effects of ANG II

-kidney- Na/H2O retention
-brain - release of corticotropin and adiuretin, thirst
-adrenals - increased aldosterone secretion
-blood vessels - vasoconstriction

25

altered peripheral resistance by ANG II

-vasoconstriction
-enhancement of peripheral noradrenergic transmission (NE release, vascular responsiveness, decreased NE reuptake)
-increased sympathetics
-catecholamine release from adrenal medulla

**rapid pressor response

26

altered renal function by ANG II

-increase Na reabsorption in proximal tubules
-aldosterone from adrenal cortex (Na reabsorption and K excretion in distal nephron)
-altered renal hemodynamics (vasoconstriction, enhanded noradrenergic, increased renal sympathetic tone)

**slow pressor response

27

altered CV function with ANG II

-non-hemodynamic effects - increased protooncogenes, increased GFs, increased ECM proteins
-hemodynamic-mediated (increased afterload, increased wall tension)

**vascular and cardiac hypertrophy and remodeling

**connection between HTN and cardiovascular disease

28

meds that block RAAS

-diuretics
-aldosterone receptor antagonist
-ACE inhibitor
-ANG II receptor blocker
-renin inhibitor
-beta-blocker

29

ACE inhibitor mechanism

-inhibit conversion of ANG I to ANG II
-also prevent degradation of bradykinin and other vasodilators

30

indications for ACE inhibitor

HTN, heart failure, left ventricular dysfunction, prophylaxis for future cerebrovascular events, and nephropathy