Intro to Antihypertensive Agents IV Flashcards Preview

RENAL II Exam 3 > Intro to Antihypertensive Agents IV > Flashcards

Flashcards in Intro to Antihypertensive Agents IV Deck (51)
Loading flashcards...
1

amlodipine

calcium channel blocker

2

clevidipine

calcium channel blocker
-DHP

3

felodipine

calcium channel blocker
-DHP

4

isradipidine

calcium channel blocker
-DHP

5

nicardipine

calcium channel blocker
-DHP

6

nifedipine

calcium channel blocker
-DHP

7

nisoldipine

calcium channel blocker
-DHP

8

diltiazem

calcium channel blocker
-non-DHP

9

verapamil

calcium channel blocker
-non-DHP

10

diazoxide

K channel opener

11

minoxidil

K channel opener

12

fenoldopam

dopamine agonist

13

hydralaine

NO donor

14

nitroprusside

NO donor
-nitropress

15

nitroglycerin

NO donor
-organic nitrate

16

isosorbide dinitrate

NO donor
-organic nitrate

17

calcium channel blocker mechanism

block L-type Ca channels
-cardiac myocyte and SA and AV nodal cells

decreased vascular smooth m contraction

18

dihydropyridine mechanism

-bind L-type Ca channels
-arteriolar vasodilation predominant

**more vascular effect

19

non-dihydropyridine mechanism

-bind L-type Ca channels
-predominant cardiac effects, but also act at vascular tissues

verapamil > diltiazem

20

hemodynamics of CCBs

-reduced TPR
-reduced afterload
-reduced O2 demand
-non-DHPs reduce CO
-decreased coronary vascular resistance and increased coronary blood flow

21

CCBs and cardiac muscle

negative inotropic effect
-Na fast channel primary depolarization, but Ca slow channels is additional
-Ca entry - induce Ca release from SR
-Ca binds troponin - allows contraction

verapamil > diltiazem > DHPs (inotropic effects)

22

DHPs

relax vascular smooth m at lower concentration than required for direct action on heart

23

DHPs and cardiac muscle

greater vasodilatory effect
-reflex increased sympathetic tone that overcomes negative inotropic effect

24

CCB effect on cardiac nodal cells

SA and AV node - depolarization L-type Ca channels

DHPs block channel - but don't effect recovery of channel and ARE NOT frequency dependent

25

verapamil and diltiazem

non-DHP CCB
-block channel, delay recovery of channel, and ARE frequency dependent

-decreased rate of SA node depolarization and slow AV nodal conduction

-useful for Tx of supraventricular tachyarrhythmias but dangerous for patients with slow nodal conduction

26

non-DHPs

more cardiac effect
-decreased contractility, suppress SA automaticity, and AV conduction

27

CCB pharmacokinetics

high 1st pass effect

28

long half life CCBs

amlodipine, felodipine, isradipine

29

DHP with long plasma half lives **

preferred to minimize reflex cardiac effects

-**decreased reflex tachycardia

-release preparations are available

30

CCBs sometimes used IV

nifedipine, clevidipine, verapamil, diltiazem