citric acid cycle Flashcards
what is the ultimate point of the citric acid cycle
metabolise all fuels-
carbs, fatty acids and amino acids
where does the CAC happen
matrix of mitochondria
whats the starting molecule for CAC
acetyl CoA
how is acetyl CoA made from carbohydrates
glycolysis produces pyruvate
which is turned into acetyl CoA by
pyruvate dehydrogenase
how is acetyl CoA made from fatty acids
beta oxidation creates acetyl CoA
in the CAC: NADH gets made at reactions
3,4,8
2 each time so 6 is made in total
(when NADH gets made it means NAD+is used)
FADH gets made at reaction
6
CO2 is made at reactions
3,4 and when making Acetyl CoA from pyruvate
pyruvate carboxylase converts
pyruvate to oxaloacetate only when acetyl CoA is present
anabolic pathways: what can citrate make
fatty acids and sterols
anabolic pathways: whats can alpha ketoglutarate make
amino acids (glutamine, proline, arginine, glutamate)
purines
anabolic pathways: oxaloacetate can be made into
amino acids (aspartate, asparagine)
pyrimidines
terminal respiration: step 1, complex 1
NADH (from CAC) gives an electron to Complex I
I gets supercharged and lets H+ (protons) across from the matrix to the intermembrane space
1 then psses its electron to Co Q
terminal respiration: step 2, complex 2
FADH2 gives electrons to II
II passes electron to Co Q
CoQ gives electrons to III
terminal respiration: step 3, complex 3
III gets supercharged and lets H+ in
III passes electrons to Cytochrome C
which passes electrons to IV
