pharmacology Flashcards
(22 cards)
example of lipid soluble signalling molecules
i.e intracellular receptors
nitric oxide
steroid hormones
cell surface receptors
for hydrophilic molecules
- receptor channels
- G protein couples receptors
- receptor enzymes
- integrin receptors
cell surface receptor: receptor channels
also called ionotropic
e.g nicotinic ACh receptors in the neuromuscular junction
cell surface receptor: G protein coupled receptors
metabotropic receptors
have a middle man- G protein
can affect ion channels and AP’s
the G protein can break off and activate something else- second messenger
cell surface receptor: receptor enzymes
have intrinsic enzyme activity- insulin receptors
or
are bound to an enzyme- cytokine rceptors
cell surface receptor: integrin receptors
receptors that interact with the cytoskeleton
sources of intercellular calcium
- internal sources- IP3- or from endoplasmic reticulum
- external sources- through ligand or voltage gated channels
- inhibition of calcium transport out of the cell
what is pharmacology
the study of how living systems are affected by chemicals
affinity
the of a chemical attraction between a drug and a receptor
low EC50 indicates
HIGH affinity
efficacy
how good the drug is at activating the receptor
agonist
mimics the normal effects of a receptor
antagonist
blocks the normal action of a reseptor
affinity and efficacy of a full agonist
max affinity
max efficacy
affinity and efficacy of a partial agonist
high affinity
low efficacy
affinity and efficacy of a antagonist
max affinity
no efficacy
selective agonist/antagonist
only activate/block some types of receptors
e.g beta 2 antagonists
adrenalin works on
alpha 1 and 2
beta 1 and 2 receptors
what do alpha 1 receptors do
dilates pupils
what do alpha 1 receptors do
inhibits gastric secretion
what do beta1 receptors do
increases heart rate
what do beta 2 receptors do
dilates pupils
