Coagulation (MR) Flashcards Preview

Clinical Medicine Master > Coagulation (MR) > Flashcards

Flashcards in Coagulation (MR) Deck (34):
1

1º Coagulation involves? What type of hold does this create?

Platelets Vasculature Platelet Plug - Temporary Hold

2

2º Coagulation involves? What type of hold does this create?

Coagulation factors Antithrombotic Fibrinolytic Containment

3

The moment you turn on clotting what else are you turning on? Where? Why?

Anticlotting Periphery So your whole body doesn't clot lol

4

CX of 1º Hemostatic Disorders?

Petechia Ecchymosis Mucosal Bleeds Epistaxis - not nec small

5

CX of 2º Hemostatic Disorders?

Hemoabdomen Hemothorax Melena Hematemesis

6

What are the 3 corners of Virchow's Triad? What does it mean?

Stasis - ↓ Blood Flow Endothelial Injury (inside of bv) Hypercoagulability Balance of clottiness vs not clottiness

7

What causes stasis?

Venous Obstruction Cardiac Dz Immobility

8

What causes Endothelial Injury?

Trauma, sx Venipuncture Catheters Vasculitis

9

What causes Hypercoagulability?

Almost any dz on the planet Neoplasia Inflammation Trauma/sx MODS Sepsis Clotting Factor abnormality

10

What does Hypercoagulability lead to?

DIC used up all your clotters

11

Describe platelets? What do they consist of?

Megakaryocyte fragments Proteins Glycoproteins Channels Granules

12

Can you do advanced diagnostic testing on low platelets? Why?

NO Because if there are only 4, they could

13

TQ!!! What is the first test you will ever do on platelets?

Platelet count

14

BMBT stands for?

Buccal Mucosal Bleeding Time

15

Platelet Tests?

BMBT Clot Retraction Test

16

What is Clot Retraction Study diagnostic for? Who is predisposed to this?

Glandsmans Thrombinsthenia Great Pyrenees

17

Thromboeslatography?

Global Idea of Clotting Activity of the Animal Includes 1º & 2º Hemostasis from the beginning of clot formation through the end of breakdown

18

2º Hemostasis/Clotting Factors is which system?

Intrinsic Pathway

19

What is the only soluble clotting factor in extrinsic pathway?

7

20

What are the only 2 clotting factors in the extrinsic pathway?

7 & 3 (tissue factor)

21

Wal-Mart analogy for Intrinsic Pathway? So, what are the Factors of the Intrinsic Pathway?

It's not $12, it's $11.98. 12, 11, 9, 8

22

What is Clotting Factor #4?

Ca2+

23

What does ACT test basically tell you?

Common Pathway Intrinsic, Extrinsic, & Common Clot or No Clot

24

Thrombin Time (TT) Test is a test of?

Function of Fibrinogen (corrigan side-note: not a clinically helpful test for her)

25

One Step Prothrombin Time (OSPT)/(PT) tests which pathway(s)?

Extrinsic & Common

26

Activated Partial Thromboplastin Time (APTT)/(PTT) is a test of?

Intrinsic & Common Pathways

27

Fibrinogen/Fibrin Degradation Products Test (FDP) tests for?

Non-specific inflammation breakdown products. Clot Breakdown products. Not that useful clinically

28

D-Dimer tests for? What does this mean?

Specific Clot Breakdown 2º Fibrinolysis A clot was formed, and got digested properly.

29

What would coagulation tests most likely look like with DIC?

↑ PT, PTT, FDP, and D-Dimers Low platelet count

30

Which factor has very short t1/2? How long?

7 4-6 hours

31

TQ!!! What are the Vit K dependent factors?

2, 7, 9,10

32

Which clotting factors have a t1/2 of 1 - 2 days (12- 24 hrs)?

5, 8, 9, 10

33

Which clotting factors have a t1/2 of 2 - 3 days?

1, 2, 11, 12

34

List the Antithrombotic Proteins & Fibrinolytic Proteins?

Protein C Protein S Antithrombin Plasminogen - with its activators, inhibitors, & suppressors Urokinase Streptokinase