Flashcards in Coagulation (MR) Deck (34):
1º Coagulation involves? What type of hold does this create?
Platelets Vasculature Platelet Plug - Temporary Hold
2º Coagulation involves? What type of hold does this create?
Coagulation factors Antithrombotic Fibrinolytic Containment
The moment you turn on clotting what else are you turning on? Where? Why?
Anticlotting Periphery So your whole body doesn't clot lol
CX of 1º Hemostatic Disorders?
Petechia Ecchymosis Mucosal Bleeds Epistaxis - not nec small
CX of 2º Hemostatic Disorders?
Hemoabdomen Hemothorax Melena Hematemesis
What are the 3 corners of Virchow's Triad? What does it mean?
Stasis - ↓ Blood Flow Endothelial Injury (inside of bv) Hypercoagulability Balance of clottiness vs not clottiness
What causes stasis?
Venous Obstruction Cardiac Dz Immobility
What causes Endothelial Injury?
Trauma, sx Venipuncture Catheters Vasculitis
What causes Hypercoagulability?
Almost any dz on the planet Neoplasia Inflammation Trauma/sx MODS Sepsis Clotting Factor abnormality
What does Hypercoagulability lead to?
DIC used up all your clotters
Describe platelets? What do they consist of?
Megakaryocyte fragments Proteins Glycoproteins Channels Granules
Can you do advanced diagnostic testing on low platelets? Why?
NO Because if there are only 4, they could
TQ!!! What is the first test you will ever do on platelets?
BMBT stands for?
Buccal Mucosal Bleeding Time
BMBT Clot Retraction Test
What is Clot Retraction Study diagnostic for? Who is predisposed to this?
Glandsmans Thrombinsthenia Great Pyrenees
Global Idea of Clotting Activity of the Animal Includes 1º & 2º Hemostasis from the beginning of clot formation through the end of breakdown
2º Hemostasis/Clotting Factors is which system?
What is the only soluble clotting factor in extrinsic pathway?
What are the only 2 clotting factors in the extrinsic pathway?
7 & 3 (tissue factor)
Wal-Mart analogy for Intrinsic Pathway? So, what are the Factors of the Intrinsic Pathway?
It's not $12, it's $11.98. 12, 11, 9, 8
What is Clotting Factor #4?
What does ACT test basically tell you?
Common Pathway Intrinsic, Extrinsic, & Common Clot or No Clot
Thrombin Time (TT) Test is a test of?
Function of Fibrinogen (corrigan side-note: not a clinically helpful test for her)
One Step Prothrombin Time (OSPT)/(PT) tests which pathway(s)?
Extrinsic & Common
Activated Partial Thromboplastin Time (APTT)/(PTT) is a test of?
Intrinsic & Common Pathways
Fibrinogen/Fibrin Degradation Products Test (FDP) tests for?
Non-specific inflammation breakdown products. Clot Breakdown products. Not that useful clinically
D-Dimer tests for? What does this mean?
Specific Clot Breakdown 2º Fibrinolysis A clot was formed, and got digested properly.
What would coagulation tests most likely look like with DIC?
↑ PT, PTT, FDP, and D-Dimers Low platelet count
Which factor has very short t1/2? How long?
7 4-6 hours
TQ!!! What are the Vit K dependent factors?
2, 7, 9,10
Which clotting factors have a t1/2 of 1 - 2 days (12- 24 hrs)?
5, 8, 9, 10
Which clotting factors have a t1/2 of 2 - 3 days?
1, 2, 11, 12